{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T06:01:33Z","timestamp":1785391293311,"version":"3.55.0"},"reference-count":37,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["OVS"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To assess and compare the time\u2010dependent disinfection efficacy against standard microbial strains and the neutralization kinetics of two commercially available soft contact lens care systems, one based on 0.05% povidone iodine and one based on 3.42% hydrogen peroxide.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      To assess neutralization kinetics of each system, the concentration of the active disinfectants was quantified via iodometric titration (hydrogen peroxide) and high\u2010performance liquid chromatography (povidone iodine) at intervals from 0.5\u00a0min to the minimum recommended disinfection time (MRDT). Disinfecting efficacy against the five ISO 14729 microbial strains (\n                      <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n                      ,\n                      <jats:italic>Serratia marcescens<\/jats:italic>\n                      ,\n                      <jats:italic>Staphylococcus aureus<\/jats:italic>\n                      ,\n                      <jats:italic>Candida albicans<\/jats:italic>\n                      ,\n                      <jats:italic>Fusarium solani<\/jats:italic>\n                      ) was assessed at intervals from 0.5\u00a0min to each system's respective MRDT. Microbial log reductions and disinfection rates were calculated using standard plate count methods. Statistical significance between systems was determined using ANOVA and post\u2010hoc comparisons (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The povidone iodine system reached a peak concentration (\u223c0.05%) within 2\u00a0min, maintained this level for 5\u00a0min, and was neutralized by 20\u00a0min. Despite rapid neutralization, povidone iodine exceeded the standardized criteria for all strains within 1\u00a0min and disinfected below the detectable limit within 5\u00a0min. Conversely, the hydrogen peroxide system's concentration began declining immediately and fell below 1% within 30\u00a0min, before disinfection was complete for three strains. Significant kinetic differences (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05) favored povidone iodine across four strains, most notably against\n                      <jats:italic>S. aureus<\/jats:italic>\n                      , where hydrogen peroxide lagged by several hours.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study possesses a conflict of interest, and external validation is encouraged. The povidone iodine system achieved remarkably rapid disinfection across all strains at a 5000\u2010fold lower molar concentration than the hydrogen peroxide system, well below the ocular irritation threshold. Povidone iodine's consistent, rapid disinfection, along with its high safety profile, suggests it may be a more optimal care option than the current gold standard.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ovs2.70085","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T03:19:22Z","timestamp":1782789562000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparison of neutralization and disinfection kinetics in povidone iodine\u2010 and hydrogen peroxide\u2010based soft contact lens care solutions"],"prefix":"10.1002","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3938-799X","authenticated-orcid":false,"given":"Charles","family":"Bahr","sequence":"first","affiliation":[{"name":"Kobe Laboratory Ophtecs Corporation  Kobe Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megumi","family":"Kitamura","sequence":"additional","affiliation":[{"name":"Kobe Laboratory Ophtecs Corporation  Kobe Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruki","family":"Nakagawa","sequence":"additional","affiliation":[{"name":"Kobe Laboratory Ophtecs Corporation  Kobe Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiro","family":"Sasanuma","sequence":"additional","affiliation":[{"name":"Kobe Laboratory Ophtecs Corporation  Kobe Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuhide","family":"Yamasaki","sequence":"additional","affiliation":[{"name":"Kobe Laboratory Ophtecs Corporation  Kobe Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumio","family":"Saitoh","sequence":"additional","affiliation":[{"name":"Kobe Laboratory Ophtecs Corporation  Kobe Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,29]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clae.2021.02.010"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/ceo.14113"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.2147\/OPTO.S66424"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2018.12.003"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0181343"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICL.0b013e3182713919"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41433\u2010023\u201002404\u20103"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.16796"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2011.288"},{"key":"e_1_2_8_11_1","volume-title":"Ophthalmic optics \u2014 contact lens care products \u2014 microbiological requirements and test methods for products and regimens for hygienic management of contact lenses","author":"International Organization for Standardization (ISO). 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