{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T07:01:11Z","timestamp":1771138871551,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T00:00:00Z","timestamp":1766188800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T00:00:00Z","timestamp":1766188800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Anesthesia"],"published-print":{"date-parts":[[2026,3]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n \n Dexmedetomidine is an a\n 2<\/jats:sub>\n \u2010adrenoreceptor agonist with sedative, analgesic, and anxiolytic properties. It has gained remarkable attention in the adult and pediatric population predominantly because of its minimal respiratory depression. However, in the pediatric population, very limited information is available regarding the action of intravenous dexmedetomidine on neuromuscular blockade and on anesthesia induction. The aim of this study was to investigate the impact of dexmedetomidine on rocuronium\u2010induced neuromuscular blockade and on anesthesia induction with propofol in children.\n <\/jats:p>\n <\/jats:sec>\n \n Material and Method<\/jats:title>\n A total of 60 children undergoing elective surgery, ages 4\u201312\u2009years, were enrolled in the study. Before the induction of anesthesia with propofol, 30 children received dexmedetomidine 0.5\u2009\u03bcg\/kg given over 10\u2009min (group D). Another group of 30 children received the same volume of N\/S 0.9% over 10\u2009min as well (group P). We recorded time to achieve TOF\u2009=\u20090 from the end of rocuronium infusion, time for BIS <\u200960 from the end of propofol infusion, intubation conditions, haemodynamic changes, intubation attempts, and adverse effects.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The onset time of rocuronium was significantly lower in group D compared to group P (177.8\u2009s, 95% CI 161.1\u2013194.0\u2009s vs 205\u2009s, 95% CI 188.0\u2013222.0\u2009s;\n p<\/jats:italic>\n \u2009=\u20090.021). Time for BIS to reach a value <\u200960 (34.3\u2009s, 95% CI 29.1\u201339.6\u2009s for group D vs 33.2\u2009s, 95% CI 27.2\u201339.2\u2009s for group P,\n p<\/jats:italic>\n \u2009=\u20090.772) was unaffected by dexmedetomidine infusion. Intubation conditions showed a more stable haemodynamic response in group D (systolic, diastolic, mean arterial pressure, and heart rate were significantly lower in group D at intubation). No difference was found regarding intubation attempts and adverse effects.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Our results showed that dexmedetomidine infusion before induction of anesthesia with propofol reduced the onset time of rocuronium and provided a better hemodynamic profile during endotracheal intubation in children.<\/jats:p>\n <\/jats:sec>\n \n Trial Registration<\/jats:title>\n \n The study protocol was registered in\n ClinicalTrials.gov<\/jats:ext-link>\n (NCT03923075)\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/pan.70098","type":"journal-article","created":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T08:35:21Z","timestamp":1766219721000},"page":"316-325","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of Dexmedetomidine on Rocuronium\u2010Induced Neuromuscular Blockade and Intubation Condition in Children: A Randomized Controlled Trial"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2033-8298","authenticated-orcid":false,"given":"Niki","family":"Kouna","sequence":"first","affiliation":[{"name":"2nd<\/sup> Department of Anaesthesiology School of Medicine, National and Kapodistrian University of Athens, \u2018Attikon\u2019 University Hospital Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paraskevi","family":"Matsota","sequence":"additional","affiliation":[{"name":"2nd<\/sup> Department of Anaesthesiology School of Medicine, National and Kapodistrian University of Athens, \u2018Attikon\u2019 University Hospital Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,20]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40262\u2010017\u20100507\u20107"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/PEC.0b013e3182495e1b"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjane.2016.02.007"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/EJA.0000000000001350"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.25107\/2638\u20104558.1612"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/20587392211000578"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00540\u2010011\u20101270\u20109"},{"key":"e_1_2_10_9_1","first-page":"203","article-title":"The Effects of Dexmedetomidine on Hemodynamic Parameters and Intubation Conditions","volume":"59","author":"Yildirim A.","year":"2019","journal-title":"Haydarpasa Numune Medical Journal"},{"key":"e_1_2_10_10_1","first-page":"337","article-title":"Effects of Dexmedetomidine Hydrochloride on Cisatracurium\u2010Induced Neuromuscular Blockade in Geriatric Different Aged Patients","volume":"35","author":"Liu Q.","year":"2016","journal-title":"Herald of Medicine"},{"key":"e_1_2_10_11_1","first-page":"110","article-title":"Effects of Two Different Doses of Dexmedetomidine on Intraoperative Desflurane Consumption, Hemodynamic Parameters and Neuromuscular Blockade","volume":"31","author":"Aliyeva A.","year":"2009","journal-title":"Erciyes Tip Dergisi (Erciyes Medical Journal)"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1213\/01.ane.0000260317.02748.83"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/74.4.455"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cacc.2007.07.001"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000539\u2010199903000\u201000031"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399\u20106576.1996.tb04389.x"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.4103\/aer.AER_45_18"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000000812"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399\u20106576.2005.00780.x"},{"issue":"14","key":"e_1_2_10_20_1","first-page":"3134","article-title":"Effect of Different Doses of Dexmedetomidine on Median Effective Concentration of Propofol for Anesthesia Induction: A Randomized Controlled Trial","volume":"20","author":"Zhao X. 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