{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T06:17:37Z","timestamp":1775542657867,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T00:00:00Z","timestamp":1772841600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T00:00:00Z","timestamp":1772841600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Anesthesia"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Acute and postoperative pain in children is often undertreated, with effects on patient comfort and postoperative recovery. Extended reality (XR) interventions offer non\u2010pharmacological pain management by distracting patients from discomfort. While effective for procedural pain, its impact on prolonged pain episodes remains underexplored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To systematically review and meta\u2010analyze findings from previous studies on the efficacy of XR interventions in managing acute and postoperative pain in children, compared to standard care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Eligibility Criteria<\/jats:title>\n                    <jats:p>Studies involving children (\u2264\u200918\u2009years) with acute or postoperative pain were included if they compared XR interventions to standard care. Studies focusing on procedural or chronic pain were excluded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic search was conducted on January 23, 2025, in MEDLINE, EMBASE, Web of Science, CINAHL, and PsycINFO for studies evaluating XR interventions for acute and postoperative pain in children, using validated pain measures. Pain outcomes were extracted for an exploratory meta\u2010analysis, with self\u2010report as the primary and observer\u2010report as the secondary outcome. Two reviewers independently extracted data and assessed study quality using CONSORT and TREND.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      From 1793 records, nine studies were included, all evaluating virtual reality (VR) interventions. Seven focused on postoperative pain, two on acute pain. The primary meta\u2010analysis (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20096) showed a moderate but nonsignificant effect in self\u2010reported pain (SMD\u2009=\u2009\u22120.61; 95% CI, \u22121.58 to 0.36). The secondary meta\u2010analysis (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20096) for observer\u2010reported pain showed a large but nonsignificant effect (SMD\u2009=\u2009\u22121.04; 95% CI, \u22122.18 to 0.11).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This meta\u2010analysis found no significant analgesic effect of VR on acute or postoperative pain in children. However, moderate effect sizes were observed, but the lack of statistical significance indicates that XR interventions require further investigation in pediatric pain management. Future research should prioritize pain as a primary endpoint and assess the effects of VR type, timing, and age on acute pain using validated measures.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pan.70157","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T19:59:28Z","timestamp":1772999968000},"page":"479-490","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Analgesic Effect of Extended Reality (\n                    <scp>XR<\/scp>\n                    ) on Acute and Postoperative Pain in Children: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-6598-8898","authenticated-orcid":false,"given":"Louise","family":"Meulenkamp\u2010Yilmaz","sequence":"first","affiliation":[{"name":"Department of Child and Adolescent Psychiatry\/Psychology Erasmus MC Sophia Children's Hospital, University Medical Center Rotterdam  Rotterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Souraya","family":"El Bardai","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Psychiatry\/Psychology Erasmus MC Sophia Children's Hospital, University Medical Center Rotterdam  Rotterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manon H. J.","family":"Hillegers","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Psychiatry\/Psychology Erasmus MC Sophia Children's Hospital, University Medical Center Rotterdam  Rotterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeroen","family":"Legerstee","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Psychiatry\/Psychology Erasmus MC Sophia Children's Hospital, University Medical Center Rotterdam  Rotterdam the Netherlands"},{"name":"Research Institute of Child Development and Education, University of Amsterdam  Amsterdam the Netherlands"},{"name":"Levvel Mental Health Center  Duivendrecht the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bram","family":"Dierckx","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Psychiatry\/Psychology Erasmus MC Sophia Children's Hospital, University Medical Center Rotterdam  Rotterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lonneke","family":"Staals","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Erasmus MC Sophia Children's Hospital, University Medical Center Rotterdam  Rotterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,7]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redar.2016.11.006"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2018.07.006"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.17219\/acem\/112600"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005\u20102920"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1213\/ane.0b013e3181b412cf"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j..2004.00192.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440\u2010172X.2012.02016.x"},{"key":"e_1_2_6_9_1","unstructured":"International Association for the Study of Pain (IASP) \u201cAcute Pain \u201daccessed December 11 2025 https:\/\/www.iasp\u2010pain.org\/resources\/topics\/acute\u2010pain\/."},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/children4070052"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000004165"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/pan.14546"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11936\u2010019\u20100722\u20107"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u20103\u2010030\u201047483\u20106_7"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0b013e31824d5224"},{"issue":"2","key":"e_1_2_6_16_1","first-page":"114","article-title":"The Effect of Music Distraction on Pain, Anxiety and Behavior in Pediatric Dental Patients","volume":"24","author":"Aitken J. 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