{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T20:12:51Z","timestamp":1783455171418,"version":"3.55.0"},"reference-count":27,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T00:00:00Z","timestamp":1779667200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T00:00:00Z","timestamp":1779667200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005744","name":"Lastentautien Tutkimuss\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005744","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Anesthesia"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To conduct a meta\u2010analysis of postoperative outcomes following the use of regional anesthesia in pediatric cardiac surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Sources<\/jats:title>\n                    <jats:p>We searched PubMed (MEDLINE), Web of Science, CINAHL, CENTRAL, and Scopus in December 2024 (PROSPERO: CRD420025635423; registered January 2025).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Selection<\/jats:title>\n                    <jats:p>Two authors screened search results. We included parallel\u2010grouped randomized controlled trials (RCT) regardless of blinding. Studies comparing adjuvant regional anesthesia (excluding neuraxial anesthesia) with general anesthesia in pediatric patients (0\u201317\u2009years) having cardiac surgery via midline sternotomy were included.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Extraction<\/jats:title>\n                    <jats:p>Two authors independently extracted the data and assessed risk of bias. The main outcome measures were pain relief using any documented pain score and duration of mechanical ventilation. Other outcome measures sought were postoperative opioid consumption, time to first rescue analgesia, time in pediatric intensive care unit (PICU), length of hospital stay, complications, and patient satisfaction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Synthesis<\/jats:title>\n                    <jats:p>We identified 15 RCTs with 1055 participants for the analysis. Pain scores were lower during the first 24\u2009h postoperatively, with Modified Objective Pain Scale (MOPS) mean difference (MD) being 0.76 less (MD \u22120.76; CI \u22121.19 to \u22120.32). Duration of mechanical ventilation was 48\u2009min shorter in the regional anesthesia group (MD \u221248; CI \u221260 to \u221236). Postoperative cumulative opioid consumption (morphine equivalents) was 0.21\u2009mg\/kg lower (MD \u22120.21; CI \u22120.30 to \u22120.11). No complications related to regional anesthesia were reported.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our meta\u2010analysis demonstrates that regional anesthesia in pediatric cardiac surgery reduces postoperative pain, as measured by pain scores and postoperative opioid consumption, leads to shorter mechanical ventilation and PICU stays.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pan.70229","type":"journal-article","created":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T13:51:22Z","timestamp":1779717082000},"page":"899-907","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of Intraoperative Regional Anesthesia on Postoperative Outcomes in Pediatric Cardiac Surgery\u2014A Systematic Review of Randomized Controlled Trials"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-3740-3970","authenticated-orcid":false,"given":"Katariina","family":"Hiisivuori","sequence":"first","affiliation":[{"name":"Department of Anesthesia and Intensive Care Helsinki University Hospital  Helsinki Finland"},{"name":"Pediatric Research Centre University of Helsinki  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0565-0593","authenticated-orcid":false,"given":"Heli","family":"Salmi","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Intensive Care Helsinki University Hospital  Helsinki Finland"},{"name":"Pediatric Research Centre University of Helsinki  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vesa K.","family":"Kontinen","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Intensive Care Helsinki University Hospital  Helsinki Finland"},{"name":"Clinicum, Faculty of Medicine University of Helsinki  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8178-9610","authenticated-orcid":false,"given":"Ilari","family":"Kuitunen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kuopio University Hospital  Kuopio Finland"},{"name":"Institute of Clinical Medicine University of Eastern Finland  Kuopio 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