{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T05:53:36Z","timestamp":1791266016032,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002679","name":"Adnan Menderes \u00dcniversitesi","doi-asserted-by":"publisher","award":["DHF\u201024002"],"award-info":[{"award-number":["DHF\u201024002"]}],"id":[{"id":"10.13039\/501100002679","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Anesthesia"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>In pediatric anesthesia, minimum alveolar concentration (MAC) guides inhalational agent dosing but may not accurately reflect anesthetic depth. EEG\u2010guided anesthesia has shown benefits in adults but remains underused in children.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This study aims to evaluate the effect of EEG\u2010guided anesthesia with SedLine on emergence delirium (ED) and sevoflurane dose in behaviorally noncompliant children undergoing dental procedures under general anesthesia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this prospective, randomized controlled trial, 100 children aged 4\u201310\u2009years were randomized to standard anesthesia guided by MAC and conventional clinical signs (standard group) or EEG\u2010guided anesthesia titrated to SedLine parameters (primary target: PSI 25\u201350; secondary parameter: SEF 10\u201315\u2009Hz) (EEG\u2010S group). Primary outcome was ED incidence assessed by the Pediatric Anesthesia Emergence Delirium Scale (PAEDS). Secondary outcomes included mean EtSevo values, postoperative pain, rescue analgesia, nausea\/vomiting, recovery time.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Median PAEDS scores during the first 120\u2009min postoperatively were significantly lower in the EEG\u2010S group compared with the Standard group (e.g., upon arrival to PACU: 4 [IQR 4] vs. 8 [IQR 4.5]). In addition, the incidence of ED upon arrival in the recovery room was significantly lower in the EEG\u2010S group (17% vs. 43%) and at 10\u2009min postoperatively (17% vs. 37%). The mean end\u2010tidal sevoflurane concentration was statistically lower in the EEG\u2010S group (maintenance EtSevo 1.88\u2009\u00b1\u20090.25 vs. 1.98\u2009\u00b1\u20090.20; mean difference\u2009=\u20090.10, 95% confidence interval: 0.006\u20130.190;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.036). Postoperative FLACC pain scores were also lower in the EEG\u2010S group, representing a potential confounding factor for ED outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>EEG\u2010guided anesthesia was associated with lower PAEDS scores and reduced sevoflurane consumption compared with standard management. However, given small EEG\u2010derived differences and potential confounding by postoperative pain, these findings should be interpreted cautiously. Within the applied target ranges, EEG\u2010derived parameters were not independently associated with ED, and specific EEG targets predictive of ED could not be identified.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>\n                      This study was registered (Protocol Registration Receipt NCT06400706\/OKocaturk\/May 02 2024) at\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.clinicaltrial.gov\">http:\/\/www.clinicaltrial.gov<\/jats:ext-link>\n                    <\/jats:p>\n                  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Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7978-8715","authenticated-orcid":false,"given":"Sultan","family":"Keles","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry, Faculty of Dentistry Aydin Adnan Menderes University  Aydin 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