{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T12:53:29Z","timestamp":1791032009532,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T00:00:00Z","timestamp":1790985600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T00:00:00Z","timestamp":1790985600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Anesthesia"],"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n Sugammadex may interact with steroidal compounds; however, comparative clinical data on different peri\u2010operative corticosteroids in children are limited. This randomized controlled trial primarily aimed to compare the effect of methylprednisolone and dexamethasone, administered at clinically equivalent glucocorticoid doses, on sugammadex\u2010mediated reversal time of rocuronium\u2010induced neuromuscular block in children. Secondary aims were to compare extubation time, postoperative nausea, pain, and adverse events related to upper airway oedema between groups.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Sixty children undergoing adenotonsillar surgery were randomized 1:1:1 to receive methylprednisolone 1\u2009mg\u2009kg\n \u22121<\/jats:sup>\n , dexamethasone 0.2\u2009mg\u2009kg\n \u22121<\/jats:sup>\n , or no corticosteroid (control). Neuromuscular monitoring followed the Good Clinical Research Practice in pharmacodynamic studies of neuromuscular blocking agents standards. The primary endpoint was the rocuronium reversal time: interval from the sugammadex bolus at train of four count\u2009=\u20092 to a normalized train of four ratio of 0.9. Extubation time (interval from the sugammadex bolus at a train of four count\u2009=\u20092 until tracheal extubation); severity scores for postoperative pain and nausea; and frequency of adverse events related to upper airway oedema were the secondary endpoints. Between\u2010group comparisons used one\u2010way ANOVA or Welch's ANOVA for normally distributed data and the Kruskal\u2013Wallis test for non\u2010normally distributed data, with Bonferroni\u2010corrected post hoc pairwise comparisons.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The study population had a mean\u2009\u00b1\u2009SD age, weight, and height of 7.9\u2009\u00b1\u20092.0\u2009years, 30.0\u2009\u00b1\u20099.3\u2009kg, and 129.0\u2009\u00b1\u200911.0\u2009cm, respectively, with comparable demographic and baseline profiles across groups. Reversal time was longer with methylprednisolone (mean\u2009\u00b1\u2009SD: 82.8\u2009\u00b1\u200916.1\u2009s) than with dexamethasone (63.4\u2009\u00b1\u200913.4\u2009s) and control (56.1\u2009\u00b1\u200913.7\u2009s) (\n p<\/jats:italic>\n \u2009<\u20090.001). Extubation time showed a similar pattern. Postoperative nausea\u2010vomiting, pain scores, and the overall incidence of adverse events did not differ significantly between groups.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n At clinically equivalent glucocorticoid doses, methylprednisolone was associated with longer sugammadex\u2010mediated reversal and extubation time than dexamethasone and control, while postoperative pain, nausea scores, and adverse event rates were comparable between the groups. These findings indicate that the corticosteroid selected for peri\u2010operative use may influence the efficacy of sugammadex\u2010mediated reversal in children.<\/jats:p>\n <\/jats:sec>\n \n Trial Registration<\/jats:title>\n \n ClinicalTrials.gov<\/jats:ext-link>\n Identifier: NCT07175623\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/pan.70322","type":"journal-article","created":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T12:10:06Z","timestamp":1791029406000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparison of Methylprednisolone and Dexamethasone in Their Interaction With Sugammadex in Pediatric Patients: A Randomized Controlled Trial"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2990-3751","authenticated-orcid":false,"given":"Mustafa","family":"B\u00fcy\u00fckcavlak","sequence":"first","affiliation":[{"name":"Department of Algology, Faculty of Medicine Hacettepe University Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9905-8856","authenticated-orcid":false,"given":"Yasin","family":"Tire","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Reanimation University of Health Sciences, Konya City Hospital Konya Turkey"},{"name":"Outcome Research Consortium Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7114-2239","authenticated-orcid":false,"given":"Mehmet","family":"Sar\u0131","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Reanimation, Faculty of Medicine Bezmialem Vakif University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-0215-4023","authenticated-orcid":false,"given":"Cansu","family":"\u00c7iftci","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Reanimation University of Health Sciences, Konya City Hospital Konya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1213\/ANE.0b013e3182652a6a","article-title":"A Comparison Between Dexamethasone and Methylprednisolone for Vomiting Prophylaxis After Tonsillectomy in Inpatient Children: A Randomized Trial","volume":"115","author":"Aouad M. 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