{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T15:24:04Z","timestamp":1765293844780,"version":"build-2065373602"},"reference-count":63,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2001,11,28]],"date-time":"2001-11-28T00:00:00Z","timestamp":1006905600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[2002,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>E\u2010cadherin\/catenin (\u03b1\u2010, \u03b2\u2010, and \u03b3\u2010) complex plays a critical role in the control of epithelial differentiation. The aim of this study was to examine the immunoreactivity of E\u2010cadherin and \u03b1\u2010, \u03b2\u2010, and \u03b3\u2010catenins in premalignant and malignant non\u2010melanocytic skin tumours (NMST) and to correlate their expression with the grade of tumour differentiation, as assessed by the established histopathological criteria and by the Ki\u201067 index. Benign NMSTs were also studied. To investigate any possible influence of immunosuppression in the expression of E\u2010cadherin and catenins, the study compared tumours obtained from renal transplant recipients (RTRs) and immunocompetent patients. Immunoperoxidase staining of E\u2010cadherin and \u03b1\u2010, \u03b2\u2010, and \u03b3\u2010catenins was performed in 42 squamous cell carcinomas (SCCs) (26 from RTRs and 16 from non\u2010RTRs), 30 lesions of Bowen's disease (11 from RTRs and 19 from non\u2010RTRs), 11 atypical squamoproliferative lesions from RTRs, 19 actinic keratoses (9 from RTRs and 10 from non\u2010RTRs), and 20 viral warts from RTRs. The findings of this study were as follows. Firstly, the probability of abnormal expression of E\u2010cadherin and \u03b1\u2010, \u03b2\u2010, and \u03b3\u2010catenins increased from benign to premalignant and malignant NMSTs (<jats:italic>p<\/jats:italic>&lt;0.001 for all). Secondly, there was agreement in abnormal expression between most of the molecules measured in malignant and premalignant NMSTs (<jats:italic>p<\/jats:italic>&lt;0.05). Thirdly, in SCC, abnormal expression of E\u2010cadherin and catenins was more frequent in lesions with a high (&gt;40%) Ki\u201067 index than in those with a low Ki\u201067 index (&lt;40%) (<jats:italic>p<\/jats:italic>=0.003). However, only the abnormal expression of \u03b3\u2010catenin increased with the grade of SCC differentiation (<jats:italic>p<\/jats:italic>=0.008). Fourthly, abnormal expression of \u03b3\u2010catenin predicted a high proliferation index (Ki\u201067 index 40%) in NMSTs (<jats:italic>p<\/jats:italic>&lt;0.01, OR=6.19). Finally, there was no difference in the abnormal expression of E\u2010cadherin and catenins between NMSTs from immunosuppressed and immunocompetent patients. Thus, abnormal expression of the E\u2010cadherin\/catenin complex was quite common in SCC and Bowen's disease and also in a proportion of intraepithelial dysplastic lesions, such as atypical squamoproliferative lesions and actinic keratosis, suggesting that these changes may be early indicators of the neoplastic process. Abnormal expression of \u03b3\u2010catenin was the sole predictor of high proliferation in NMST and was also correlated with the tumour grade, suggesting a possible important role for \u03b3\u2010catenin in tumourigenesis. Copyright \u00a9 2001 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/path.1019","type":"journal-article","created":{"date-parts":[[2002,10,6]],"date-time":"2002-10-06T07:25:39Z","timestamp":1033889139000},"page":"154-162","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Abnormal immunoreactivity of the E\u2010cadherin\/catenin (\u03b1\u2010, \u03b2\u2010, and \u03b3\u2010) complex in premalignant and malignant non\u2010melanocytic skin tumours"],"prefix":"10.1002","volume":"196","author":[{"given":"Evangelia","family":"Papadavid","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Pignatelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Spyridon","family":"Zakynthinos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Krausz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony C.","family":"Chu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,11,28]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2006419"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1988.tb03249.x"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.116.4.989"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.135.1.215"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.104.3.751"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-0674(97)80122-6"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.127.5.1375"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.8259519"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1994.2631"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/382638a0"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.108.6.2435"},{"key":"e_1_2_5_13_2","first-page":"3585","article-title":"Reduction of E\u2010cadherin levels and deletion of \u03b1\u2010catenin gene in human prostate cancer cells","volume":"53","author":"Morton RA","year":"1993","journal-title":"Cancer Res"},{"key":"e_1_2_5_14_2","first-page":"5770","article-title":"Cadherin dysfunction in a human cancer cell line: possible involvement of loss of \u03b1\u2010catenin expression in reduced cell\u2013cell adhesiveness","volume":"52","author":"Shimoyama Y","year":"1992","journal-title":"Cancer Res"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.11.4246"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(90)90506-A"},{"key":"e_1_2_5_17_2","first-page":"4722","article-title":"Transition from the noninvasive to the invasive phenotype and loss of \u03b1\u2010catenin in human colon cancer cells","volume":"55","author":"Vermeulen SJ","year":"1995","journal-title":"Cancer Res"},{"key":"e_1_2_5_18_2","first-page":"6282","article-title":"A truncated \u03b2\u2010catenin disrupts the interaction between E\u2010cadherin and \u03b1\u2010catenin. 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