{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T11:08:27Z","timestamp":1790507307632,"version":"4.1.0"},"reference-count":16,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2001,12,3]],"date-time":"2001-12-03T00:00:00Z","timestamp":1007337600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[2002,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The expression of type I collagen has been compared in fibroblast and osteoblast cultures of a patient with moderately severe osteogenesis imperfecta (OI) type IV, with respect to control cells. Electrophoretic analysis of type I collagen showed that both OI osteoblasts and fibroblasts synthesized normal chains and chains with delayed migration. However, the osteoblasts contained a higher proportion of abnormal chains than fibroblasts from the proband. Pulse\u2010chase experiments showed that the trimers containing abnormal chains were cleared more rapidly from osteoblasts than fibroblasts. Moreover, the collagen secreted by OI osteoblasts had thermal stability 1\u00b0C higher than collagen secreted by OI fibroblasts. These results suggest that the abnormal collagen in osteoblasts may be more resistant to intra\u2010 and extracellular degradation and may thus have better survival than in fibroblasts. This finding could have implications for understanding the clinical phenotype of OI. Copyright \u00a9 2001 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/path.1030","type":"journal-article","created":{"date-parts":[[2002,10,6]],"date-time":"2002-10-06T07:25:48Z","timestamp":1033889148000},"page":"235-237","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Comparative studies of osteoblast and fibroblast type I collagen in a patient with osteogenesis imperfecta type IV"],"prefix":"10.1002","volume":"196","author":[{"given":"Anna","family":"Galicka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Slawomir","family":"Wolczynski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrzej","family":"Gindzienski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2001,12,3]]},"reference":[{"key":"e_1_2_4_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.16.2.101"},{"key":"e_1_2_4_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-198109000-00004"},{"key":"e_1_2_4_4_2","first-page":"167","article-title":"Osteogenesis imperfecta as a consequence of naturally occurring and induced mutations of type I collagen","volume":"8","author":"Cole WG","year":"1994","journal-title":"Bone Miner Res"},{"key":"e_1_2_4_5_2","first-page":"293","article-title":"Consistent linkage of dominantly inherited osteogenesis imperfecta to the type I collagen loci: COL1A1 and COL1A2","volume":"46","author":"Sykes B","year":"1990","journal-title":"Am J Hum Genet"},{"key":"e_1_2_4_6_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj2400699"},{"key":"e_1_2_4_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-1004(1998)11:5<395::AID-HUMU7>3.0.CO;2-4"},{"key":"e_1_2_4_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650070709"},{"key":"e_1_2_4_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)89655-7"},{"key":"e_1_2_4_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02557826"},{"key":"e_1_2_4_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/227680a0"},{"key":"e_1_2_4_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1975.tb02238.x"},{"key":"e_1_2_4_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)52286-9"},{"key":"e_1_2_4_14_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj2860073"},{"key":"e_1_2_4_15_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.35.21068"},{"key":"e_1_2_4_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)50063-6"},{"key":"e_1_2_4_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650110611"}],"container-title":["The Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpath.1030","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/path.1030","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T16:32:51Z","timestamp":1761064371000},"score":1,"resource":{"primary":{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/10.1002\/path.1030"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,12,3]]},"references-count":16,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2002,2]]}},"alternative-id":["10.1002\/path.1030"],"URL":"https:\/\/doi.org\/10.1002\/path.1030","archive":["Portico"],"relation":{},"ISSN":["0022-3417","1096-9896"],"issn-type":[{"value":"0022-3417","type":"print"},{"value":"1096-9896","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,12,3]]},"assertion":[{"value":"2001-03-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2001-09-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2001-12-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}