{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T07:21:27Z","timestamp":1790234487253,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2002,8,27]],"date-time":"2002-08-27T00:00:00Z","timestamp":1030406400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008672","name":"Wilhelm Sander Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100008672","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Association pour la Recherche contre le Cancer to OD"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[2002,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Epstein\u2013Barr virus (EBV)\u2010associated Hodgkin lymphoma (HL) and nasopharyngeal carcinoma (NPC) usually occur in patients without clinically manifest deficiencies in anti\u2010viral immunity. In spite of expressing viral proteins, both tumours are apparently able to escape EBV\u2010specific immunity\n                    <jats:italic>in vivo<\/jats:italic>\n                    . EBI3 is an EBV\u2010induced cytokine homologous to the interleukin (IL)\u201012 p40 subunit and can heterodimerize with IL\u201012 p35. It has been suggested that EBI3 may function to antagonize IL\u201012 and to inhibit the development of a Th1 immune response. EBI3 expression has been studied in tumour entities frequently associated with EBV infection to examine if EBI3 might contribute to local modulation of the immune response. It is shown that EBI3 is strongly expressed in Hodgkin and Reed\u2013Sternberg cells in 32 of 33 HL cases, independently of the EBV status of the tumour cells. Furthermore, EBI3 expression was detected in the epithelial tumour cells of six of 40 NPC biopsies but not in Burkitt lymphomas. The results suggest that EBI3 may be an additional component of the repertoire employed by Hodgkin and Reed\u2013Sternberg cells to inhibit an effective anti\u2010tumour or anti\u2010viral immune response. Copyright \u00a9 2002 John Wiley &amp; Sons, Ltd.\n                  <\/jats:p>","DOI":"10.1002\/path.1217","type":"journal-article","created":{"date-parts":[[2002,10,10]],"date-time":"2002-10-10T12:20:52Z","timestamp":1034252452000},"page":"310-316","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":80,"title":["Frequent expression of the Epstein\u2013Barr virus (EBV)\u2010induced gene, EBI3, an IL\u201012 p40\u2010related cytokine, in Hodgkin and Reed\u2013Sternberg cells"],"prefix":"10.1002","volume":"198","author":[{"given":"Gerald","family":"Niedobitek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doreen","family":"P\u00e4zolt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Teichmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Odile","family":"Devergne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2002,8,27]]},"reference":[{"key":"e_1_2_6_2_2","series-title":"IARC Monographs on the Evaluation of Carcinogenic Risks to Humans","volume-title":"Epstein\u2013Barr Virus and Kaposi's Sarcoma Herpesvirus\/Human Herpesvirus 8","author":"International Agency for Research on Cancer","year":"1997"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1987.tb02568.x"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/375685a0"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)90943-J"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.11.4766"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-69-5-1051"},{"key":"e_1_2_6_8_2","first-page":"879","article-title":"Expression of Epstein\u2013Barr virus genes and of lymphocyte activation molecules in undifferentiated nasopharyngeal carcinomas","volume":"140","author":"Niedobitek G","year":"1992","journal-title":"Am J Pathol"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-4141(199802)28:02<451::AID-IMMU451>3.0.CO;2-U"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V89.6.1978"},{"key":"e_1_2_6_11_2","first-page":"310","article-title":"Molecular characterization of antigen\u2010processing function in nasopharyngeal carcinoma: evidence for efficient presentation of Epstein\u2013Barr virus cytotoxic T\u2010cell epitopes by NPC cells","volume":"58","author":"Khanna R","year":"1998","journal-title":"Cancer Res"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V92.3.1020"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V92.7.2477.2477_2477_2483"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.165.1.573"},{"key":"e_1_2_6_15_2","first-page":"1152","article-title":"Expression of immune regulatory molecules in Epstein\u2013Barr virus\u2010associated nasopharyngeal carcinomas with prominent lymphoid stroma. 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