{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T10:46:14Z","timestamp":1792147574144,"version":"4.4.0"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2002,10,11]],"date-time":"2002-10-11T00:00:00Z","timestamp":1034294400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[2002,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Cat scratch disease is an infectious disease usually caused by\n                    <jats:italic>Bartonella henselae<\/jats:italic>\n                    . Within 1\u20133 weeks after inoculation, patients typically develop regional self\u2010limited lymphadenopathy. Lymph nodes reveal granulomas consisting of central necrosis, an inner rim of palisading macrophages, and an outer rim of lymphocytes and non\u2010palisading macrophages. In animals, cat\u2010scratch disease leads to an interferon\u2010\u03b3 (IFN\u03b3)\u2010mediated T\u2010helper 1 immune response, resulting in macrophage recruitment, stimulation, and thereby granuloma formation. The present study has sought to find\n                    <jats:italic>in situ<\/jats:italic>\n                    evidence for macrophage migration, activation, and cell death in human cat scratch disease. By non\u2010radioactive\n                    <jats:italic>in situ<\/jats:italic>\n                    hybridization and immunohistochemistry on serial sections, it was demonstrated that IFN\u03b3+ T lymphocytes and S100A8+, S100A9+ macrophages embrace granulomas, which consisted of S100A8\u2013, S100A9\u2013, HLA\u2010DR+, CD40+, TNF\u03b1+ macrophages. Combination of\n                    <jats:italic>in situ<\/jats:italic>\n                    end\u2010labelling and immunofluorescence revealed large numbers of DNA\u2010fragmented CD68+ cells with intact plasma membranes corresponding to apoptotic macrophages. On the basis of these data, it was hypothesized that in human cat scratch disease, S100A8+, S100A9+ macrophages continuously migrate to the granulomas. During this process, they may be activated by IFN\u03b3 T\u2010helper 1 lymphocytes and be differentiated to S100A8\u2013, S100A9\u2013sessile, HLA\u2010DR+, CD40+ antigen\u2010presenting, TNF\u03b1+ pro\u2010inflammatory macrophages forming granulomas. In parallel, macrophages undergo apoptosis in the centre of granulomata, a phenomenon that may restrict the destructive potential of macrophages and contribute to self\u2010limitation of cat scratch disease. Copyright \u00a9 2002 John Wiley &amp; Sons, Ltd.\n                  <\/jats:p>","DOI":"10.1002\/path.1229","type":"journal-article","created":{"date-parts":[[2002,11,15]],"date-time":"2002-11-15T10:53:59Z","timestamp":1037357639000},"page":"534-540","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Activation and apoptosis of macrophages in cat scratch disease"],"prefix":"10.1002","volume":"198","author":[{"given":"S","family":"Schweyer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Fayyazi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2002,10,11]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1985.02140130062031"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.6612349"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.30.2.265-274.1992"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.30.2.275-280.1992"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/23.10.1012"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2567.1999.00750.x"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.10.6427-6433.2001"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/1096-9896(2000)9999:9999<::AID-PATH664>3.0.CO;2-R"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1086\/315268"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.63.6.2367-2370.1995"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.66.12.5915-5920.1998"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1080\/10408410008984173"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.96.6.1137"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1086\/517738"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.46.2.255"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004030050442"},{"key":"e_1_2_6_18_2","first-page":"306","article-title":"Detection of a monocyte\/macrophage differentiation antigen in routinely processed paraffin\u2010embedded tissues by monoclonal antibody Ki\u2010M1P","volume":"65","author":"Radzun HJ","year":"1991","journal-title":"Lab Invest"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004280000282"},{"key":"e_1_2_6_20_2","first-page":"3","article-title":"Apoptosis, oncosis, and necrosis. An overview of cell death","volume":"146","author":"Majno G","year":"1995","journal-title":"Am J Pathol"},{"key":"e_1_2_6_21_2","first-page":"867","article-title":"Immunobiochemical and molecular biologic characterization of the cell\u2010proliferation\u2010associated nuclear antigen that is defined by monoclonal antibody Ki\u201067","volume":"138","author":"Gerdes J","year":"1991","journal-title":"Am J Pathol"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0952-7915(00)00226-0"},{"key":"e_1_2_6_23_2","first-page":"2402","article-title":"Cloning and expression of two human genes encoding calcium\u2010binding proteins that are regulated during myeloid differentiation","volume":"8","author":"Lagasse E","year":"1998","journal-title":"Mol Cell Biol"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/330080a0"},{"key":"e_1_2_6_25_2","first-page":"510","article-title":"Two calcium\u2010binding proteins associated with specific stages of myeloid cell differentiation are expressed by a subset of macrophages in inflammatory tissues","volume":"72","author":"Zwadlo G","year":"1988","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.178.2.669"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90335-2"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.175.4.1091"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1007\/s150100050028"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.155.10.4917"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.18.9833"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/358167a0"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.180.4.1499"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004030000150"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80290-1"},{"key":"e_1_2_6_36_2","first-page":"285","article-title":"Bcl\u20102 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death","volume":"80","author":"Oltvai ZN","year":"1993","journal-title":"Cell"}],"container-title":["The Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpath.1229","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/path.1229","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T17:23:01Z","timestamp":1761067381000},"score":1,"resource":{"primary":{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/10.1002\/path.1229"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,10,11]]},"references-count":35,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2002,12]]}},"alternative-id":["10.1002\/path.1229"],"URL":"https:\/\/doi.org\/10.1002\/path.1229","archive":["Portico"],"relation":{},"ISSN":["0022-3417","1096-9896"],"issn-type":[{"value":"0022-3417","type":"print"},{"value":"1096-9896","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,10,11]]},"assertion":[{"value":"2002-05-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2002-05-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2002-10-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}