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In this study, a polyclonal anti\u2010serum to human LT\u2010\u03b2 was used to investigate the distribution of LT\u2010\u03b2 by immunohistochemistry in normal and diseased tissues. In the gut, lymph nodes, spleen, and tonsil, there was some LT\u2010\u03b2 present on a variety of lymphoid cell types. In contrast, strong staining for LT\u2010\u03b2 was observed on plasma cells and a subpopulation of CD4+ T cells in tissues affected by chronic inflammatory disease or infection, for example in inflammatory bowel disease, and in lymph nodes obtained from patients with sarcoidosis and tuberculosis. In tuberculous and sarcoid lymph nodes, LT\u2010\u03b2 expression also occurred on some but not all epithelioid histiocytes within granulomas and on multi\u2010nucleated giant cells. These findings support a role for LT\u2010\u03b2 in human disease and suggest that it might represent a therapeutic target in a variety of common infective or inflammatory disorders. 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