{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T15:17:10Z","timestamp":1770477430042,"version":"3.49.0"},"reference-count":44,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2002,11,29]],"date-time":"2002-11-29T00:00:00Z","timestamp":1038528000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[2003,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Mantle cell lymphoma (MCL) is a distinct type of B\u2010cell non\u2010Hodgkin's lymphoma characterized by the t(11;14)(q13;q32) and cyclin D1 overexpression. Defects in apoptosis may contribute to pathogenesis. This study evaluated the expression of the anti\u2010apoptotic protein Mcl\u20101 in two MCL cell lines and five frozen MCL tumours (four small\u2010cell, one blastoid\/large\u2010cell) using western blot analysis. Mcl\u20101 expression was also assessed in 36 formalin\u2010fixed, paraffin wax\u2010embedded MCL tumours (24 small\u2010cell, 12 blastoid\/large\u2010cell) by immunohistochemistry. Western blot analysis revealed the expected 37 kD protein product in both MCL cell lines and in five frozen tumours, with the blastoid case having the highest expression level. Using a cut\u2010off of &gt;10% immunolabelled cells for Mcl\u20101, it was found that 12 of 36 MCL tumours were positive. Mcl\u20101\u2010positive tumours had a higher frequency of blastoid\/large\u2010cell morphology (8\/12 versus 4\/24, <jats:italic>p<\/jats:italic> = 0.009), p53 overexpression (3\/10 versus 1\/23, <jats:italic>p<\/jats:italic> = 0.04), and higher Ki67 immuno\u2010labelling (<jats:italic>p<\/jats:italic> = 0.002). It is concluded that expression of Mcl\u20101 in MCL is heterogeneous. A relatively high level of Mcl\u20101 expression correlates with high\u2010grade morphology, a high proliferative state, and p53 overexpression. Copyright \u00a9 2002 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/path.1254","type":"journal-article","created":{"date-parts":[[2002,12,10]],"date-time":"2002-12-10T08:43:28Z","timestamp":1039509808000},"page":"90-97","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":80,"title":["Expression of Mcl\u20101 in mantle cell lymphoma is associated with high\u2010grade morphology, a high proliferative state, and p53 overexpression"],"prefix":"10.1002","volume":"199","author":[{"given":"Joseph D","family":"Khoury","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L Jeffrey","family":"Medeiros","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George Z","family":"Rassidakis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy J","family":"McDonnell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lynne V","family":"Abruzzo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raymond","family":"Lai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,11,29]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"168","volume-title":"World Health Organization Classification of Tumours. 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