{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T04:42:05Z","timestamp":1792730525769,"version":"4.5.0"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2003,2,17]],"date-time":"2003-02-17T00:00:00Z","timestamp":1045440000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[2003,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Age\u2010related changes in liver function are important because they may promote susceptibility to adverse drug reactions, neurotoxicity, atherosclerosis, and other important diseases in older people. Age\u2010related changes in the rat hepatic sinusoidal endothelium, termed pseudocapillarization, have been described recently and these may contribute to hepatic impairment. The present study has examined surgical and post\u2010mortem specimens with immunohistochemistry and transmission electron microscopy to determine whether pseudocapillarization also occurs in older humans. The age of the subject, independent of systemic disease or hepatic pathology in surgical and post\u2010mortem samples of human liver, was associated with increased peri\u2010sinusoidal expression of von Willebrand's factor, collagen I, collagen IV, and staining with Masson's trichrome. Electron microscopy revealed significant age\u2010related thickening of the sinusoidal endothelium (young 165 \u00b1 17 nm, middle age 222 \u00b1 11 nm, older 289 \u00b1 9 nm, <jats:italic>p<\/jats:italic> &lt; 0.001) with loss of fenestrations (young 7.7 \u00b1 0.7 per 10 \u00b5m, middle age 3.6 \u00b1 0.5 per 10 \u00b5m, older 1.5 \u00b1 0.4 per 10 \u00b5m, <jats:italic>p<\/jats:italic> &lt; 0.001), and age\u2010related deposition of basal lamina and collagen. In conclusion, ageing in humans is associated with morphological changes in the sinusoidal endothelium and space of Disse which are presumptively related to the ageing process and potentially represent an important link between the ageing process and disease susceptibility. Copyright \u00a9 2003 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/path.1328","type":"journal-article","created":{"date-parts":[[2003,4,8]],"date-time":"2003-04-08T06:02:28Z","timestamp":1049781748000},"page":"112-117","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":154,"title":["Age\u2010related pseudocapillarization of the human liver"],"prefix":"10.1002","volume":"200","author":[{"given":"Allan J","family":"McLean","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria C","family":"Cogger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guan C","family":"Chong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Warren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Astrid MA","family":"Markus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane E","family":"Dahlstrom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David G","family":"Le Couteur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,2,17]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-199834050-00003"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1515\/REVEH.2002.17.1.51"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0773.2002.900406.x"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)08524-0"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/53A.5.B315"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840090222"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1053\/bega.2002.0271"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2001.22754"},{"key":"e_1_2_6_10_2","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1002\/hep.1840170222","article-title":"Clearance by the liver in cirrhosis: I. 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