{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T10:37:06Z","timestamp":1790246226578,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2003,3,3]],"date-time":"2003-03-03T00:00:00Z","timestamp":1046649600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[2003,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The present study investigated expression levels of the anti\u2010apoptotic proteins BCL\u20102, BCL\u2010XL and MCL\u20101 and the pro\u2010apoptotic proteins BAX and BCL\u2010XS in a series of 112 peripheral T\u2010cell lymphomas (PTCLs) classified according to the WHO classification. Using immunohistochemical methods and a 10% cut\u2010off, each protein was detected in a subset of PTCLs: BCL\u20102 in 46%, BCL\u2010XS in 49%, BAX in 57%, BCL\u2010XL in 57%, and MCL\u20101 in 65%. The mean percentage of positive cells for these proteins varied significantly among the PTCL types. Only two types of PTCL, ALK\u2010positive anaplastic large cell lymphoma (ALCL) and enteropathy\u2010type T\u2010cell lymphoma, had a distinctive pattern of expression; all were BCL\u20102\u2010negative and MCL\u20101\u2010positive. The mean percentage of BAX\u2010positive and BCL\u2010XS\u2010positive tumour cells was higher in ALK\u2010positive ALCL than in ALK\u2010negative ALCL or other types of PTCL (<jats:italic>p<\/jats:italic> = 0.06 and <jats:italic>p<\/jats:italic> = 0.01, respectively, Kruskal\u2013Wallis test). MCL\u20101 was detected significantly more frequently (<jats:italic>p<\/jats:italic> = 0.01, chi\u2010square test) and at higher levels (<jats:italic>p<\/jats:italic> = 0.0001, Kruskal\u2013Wallis test) in ALK\u2010positive ALCL and ALK\u2010negative ALCL than in other PTCL types. The apoptotic rate, evaluated by the TUNEL assay, correlated inversely with BCL\u20102 expression (<jats:italic>p<\/jats:italic> = 0.035). The proliferation index, assessed by the MIB\u20101 antibody, correlated with expression levels of MCL\u20101 (<jats:italic>R<\/jats:italic> = 0.42, <jats:italic>p<\/jats:italic> = 0.003), BCL\u20102 (<jats:italic>R<\/jats:italic> = 0.32, <jats:italic>p<\/jats:italic> = 0.027), BAX (<jats:italic>R<\/jats:italic> = 0.33, <jats:italic>p<\/jats:italic> = 0.014), and BCL\u2010XL (<jats:italic>R<\/jats:italic> = 0.34, <jats:italic>p<\/jats:italic> = 0.015) (Spearman rank). In conclusion, BCL\u20102 family proteins are expressed by a subset of PTCLs and their levels correlate with some histological types, apoptotic rate, and proliferation index. Expression of these proteins may explain the poor response of many types of PTCL to standard chemotherapy. These proteins may also provide novel targets for experimental therapy. Copyright \u00a9 2003 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/path.1346","type":"journal-article","created":{"date-parts":[[2003,5,13]],"date-time":"2003-05-13T07:31:16Z","timestamp":1052811076000},"page":"240-248","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":70,"title":["BCL\u20102 family proteins in peripheral T\u2010cell lymphomas: correlation with tumour apoptosis and proliferation"],"prefix":"10.1002","volume":"200","author":[{"given":"George Z","family":"Rassidakis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Preetha","family":"Ramalingam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas H","family":"Sarris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy J","family":"McDonnell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Jeffrey Medeiros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,3,3]]},"reference":[{"key":"e_1_2_6_2_2","volume-title":"Tumours of Haematopoietic and Lymphoid Tissues. 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