{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T20:19:29Z","timestamp":1761164369509,"version":"build-2065373602"},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2003,5,12]],"date-time":"2003-05-12T00:00:00Z","timestamp":1052697600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[2003,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Cyclin D3 plays a pivotal role in controlling the physiological progression from the G1 to the S phase of the cell cycle. Recent data suggest that\n                    <jats:italic>cyclin D3<\/jats:italic>\n                    may be deregulated in extranodal non\u2010Hodgkin's lymphomas (NHLs) as a consequence of the t(6;14)(p21.1;q32.3) translocation. The present study investigated for the first time by dual\u2010colour fluorescence\n                    <jats:italic>in situ<\/jats:italic>\n                    hybridization (FISH) on interphase nuclei and immunohistochemistry the prevalence of the t(6;14) translocation and cyclin D3 immunoreactivity (IR) in a series of 29 stage I\u2013IIE primary gastric NHLs (PGLs). No case showed the t(6;14) translocation. However, in five (17.2%) cases (two extranodal marginal zone lymphomas of MALT type, LGM; one diffuse large\u2010cell lymphoma with a MALT component, DLCLM; and two diffuse large\u2010cell lymphomas without a MALT component, DLCL), three to four\n                    <jats:italic>cyclin D3<\/jats:italic>\n                    signals were detected by FISH. Co\u2010hybridization with probes specific for the centromeric region and long arm of chromosome 6 indicated trisomy in one case (DLCL), whereas in the remaining four cases the pattern was highly suggestive of the presence of an isochromosome 6p. One (12.5%) case of LGM, six (75%) cases of DLCLM, and seven (53.8%) cases of DLCL (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.0378) were immunoreactive for cyclin D3. Cyclin D3 IR was detected in two (40%) of the five cases with extra\n                    <jats:italic>cyclin D3<\/jats:italic>\n                    signals and in 12 of the remaining 24 cases (50%,\n                    <jats:italic>p<\/jats:italic>\n                    = 1.000). These results suggest that the t(6;14) may represent a rare event in the pathogenesis of PGL and that cyclin D3 deregulation is most likely the result of epigenetic mechanisms. Copyright \u00a9 2003 John Wiley &amp; Sons, Ltd.\n                  <\/jats:p>","DOI":"10.1002\/path.1384","type":"journal-article","created":{"date-parts":[[2003,7,29]],"date-time":"2003-07-29T06:14:40Z","timestamp":1059459280000},"page":"596-601","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Immunoreactivity for cyclin D3 is frequently detectable in high\u2010grade primary gastric lymphomas in the absence of the t(6;14)(p21.1;q32.3) chromosomal 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