{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T07:03:37Z","timestamp":1769065417541,"version":"3.49.0"},"reference-count":55,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2003,6,3]],"date-time":"2003-06-03T00:00:00Z","timestamp":1054598400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[2003,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The murine\n                    <jats:italic>Helicobacter felis<\/jats:italic>\n                    model has been extensively used to investigate the importance of host factors in the development of chronic gastritis. The effect of gender in this murine model is unknown. Male and female C57BL\/6J mice were infected with\n                    <jats:italic>H felis<\/jats:italic>\n                    for up to 1 year. At 4, 8, 19, 36, and 52 weeks post\u2010infection, gastric histopathology, epithelial cell proliferation, and apoptosis were examined and compared with age\u2010 and gender\u2010matched controls. In female mice, infection with\n                    <jats:italic>H felis<\/jats:italic>\n                    resulted in an earlier onset of chronic gastric inflammation, epithelial hyperplasia, and oxyntic cell loss than males. In females, there was a trend towards increased gastric pathology compared with males, with long\u2010term\u2010infected female mice having significantly greater (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.05) chronic inflammation than male mice. The histopathological differences in male and female mice did not relate to the density of\n                    <jats:italic>H felis<\/jats:italic>\n                    infection. Female mice infected with\n                    <jats:italic>H felis<\/jats:italic>\n                    had significantly increased gastric epithelial cell proliferation in the cardia and corpus at both 8 and 52 weeks post\u2010infection (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.05). Epithelial cell apoptosis in the glandular mucosa of the corpus at 36 and 52 weeks post\u2010infection was significantly increased (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.05) in female mice compared with uninfected gender controls. In contrast, there was no significant increase in epithelial cell proliferation or apoptosis in any area of the stomach at any time point after\n                    <jats:italic>H felis<\/jats:italic>\n                    infection in male mice. These results demonstrate that there are gender differences in the gastric inflammatory and epithelial response to\n                    <jats:italic>H felis<\/jats:italic>\n                    in the murine model. The functional importance of gender should be considered in future murine studies on\n                    <jats:italic>H felis<\/jats:italic>\n                    \u2010 and\n                    <jats:italic>H pylori<\/jats:italic>\n                    \u2010induced chronic gastritis. Copyright \u00a9 2003 John Wiley &amp; Sons, Ltd.\n                  <\/jats:p>","DOI":"10.1002\/path.1422","type":"journal-article","created":{"date-parts":[[2003,9,25]],"date-time":"2003-09-25T03:39:13Z","timestamp":1064461153000},"page":"303-311","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["The effect of gender on\n                    <i>Helicobacter felis<\/i>\n                    \u2010mediated gastritis, epithelial cell proliferation, and apoptosis in the mouse 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