{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T23:26:58Z","timestamp":1775863618585,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2003,9,2]],"date-time":"2003-09-02T00:00:00Z","timestamp":1062460800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[2003,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Lichen planus (LP) is a chronic inflammatory disorder involving cutaneous and mucosal surfaces, characterized by a T\u2010cell\u2010mediated immune response against epithelial cells, with persistent accumulation of T lymphocytes and epithelial cell damage. The mechanisms involved in this chronic inflammatory disease are largely unknown. A pivotal role in the pathogenesis of long\u2010lasting inflammatory processes is played by the activation of nuclear factor kappa B (NF\u2010\u03baB), a primary transcription factor which upon translocation to the nucleus, binds to promoter regions of different genes encoding immune and pro\u2010inflammatory mediators. Using immunohistochemistry, the present study analysed the expression of NF\u2010\u03baB in 25 cases of cutaneous LP (CLP) and 28 cases of oral LP (OLP) and correlated this with the recruitment of cytotoxic T\u2010cells (expressing Tia\u20101 or perforin) in the inflammatory infiltrate. Nuclear NF\u2010\u03baB was expressed on basal and suprabasal keratinocytes in all cases of LP, while normal epithelium was consistently negative; OLP contained significantly higher numbers of NF\u2010\u03baB\u2010positive keratinocytes than CLP (means: 89.32 versus 22.6;\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.05). Furthermore, nuclear NF\u2010\u03baB expression by epithelial cells correlated with the amount of cytotoxic cell infiltration (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.02). These data suggest that increased NF\u2010\u03baB activity may represent the basis of maintenance of the inflammatory response. The differences observed between NF\u2010\u03baB expression on epithelial cells in OLP and CLP and their correlation with the degree of cytotoxic inflammatory infiltrate might explain the different clinical courses of the two variants of the disease, since OLP is typically more recalcitrant than CLP. As proposed for other chronic inflammatory disorders associated with increased NF\u2010\u03baB activity, the involvement of NF\u2010\u03baB in the pathogenesis of LP could be considered for selective therapeutic inhibitory targeting. Copyright \u00a9 2003 John Wiley &amp; Sons, Ltd.\n                  <\/jats:p>","DOI":"10.1002\/path.1423","type":"journal-article","created":{"date-parts":[[2003,10,28]],"date-time":"2003-10-28T03:00:42Z","timestamp":1067310042000},"page":"466-472","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":70,"title":["NF\u2010\u03baB expression in oral and cutaneous lichen 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