{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T03:10:04Z","timestamp":1761102604734,"version":"build-2065373602"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2003,7,1]],"date-time":"2003-07-01T00:00:00Z","timestamp":1057017600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[2003,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Genetic alterations that allow tumour cells to evade apoptosis have recently been identified as key features of extranodal marginal zone lymphoma of mucosa\u2010associated lymphoid tissue type (MALT\u2010type lymphoma). The t(11;18), which produces the putative anti\u2010apoptotic fusion protein API2\u2010MALT1, has been identified in a large proportion of extracutaneous MALT\u2010type lymphomas and a smaller fraction of tumours harbour mutations that inactivate the pro\u2010apoptotic functions of Fas and Bcl10. The present study has examined the status of these genes in 19 primary cutaneous B\u2010cell lymphomas (PCBCLs), 12 of which were MALT\u2010type lymphomas according to the WHO classification. None of the 19 PCBCLs carried the t(11;18) and tumour\u2010specific <jats:italic>Bcl10<\/jats:italic> alterations were not identified at the genomic level or at the mRNA level. Somatic <jats:italic>Fas<\/jats:italic> mutations causing truncation of the Fas receptor were identified in two MALT\u2010type lymphomas. Both patients with <jats:italic>Fas<\/jats:italic> mutant PCBCL exhibited benign conditions of dysregulated lymphoproliferation. One had autoimmune diabetes and rheumatoid arthritis and the other had a 25\u2010year history of recurrent cutaneous pseudo\u2010lymphomas. It is suggested that <jats:italic>Fas<\/jats:italic> mutation permits the survival and hence the accumulation of autoreactive B cells. This expansion of autoreactive B cells is analogous to the expansion of B cells chronically stimulated by exogenous antigens in the development of MALT\u2010type lymphoma. Copyright \u00a9 2003 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/path.1426","type":"journal-article","created":{"date-parts":[[2003,8,27]],"date-time":"2003-08-27T09:52:04Z","timestamp":1061977924000},"page":"134-140","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Infrequent somatic <i>Fas<\/i> mutations but no evidence of <i>Bcl10<\/i> mutations or t(11;18) in primary cutaneous MALT\u2010type lymphoma"],"prefix":"10.1002","volume":"201","author":[{"given":"Kirsten","family":"Gr\u00f8nb\u00e6k","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabeth","family":"Ralfkiaer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f6rg","family":"Kalla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gunhild L","family":"Skovgaard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Per","family":"Guldberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2003,7]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2002.1.263"},{"key":"e_1_2_6_3_2","first-page":"354","article-title":"EORTC classification for primary cutaneous lymphomas: a proposal from the Cutaneous Lymphoma Study Group of the European Organization for Research and Treatment of Cancer","volume":"90","author":"Willemze R","year":"1997","journal-title":"Blood"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199711000-00005"},{"volume-title":"World Health Organisation Classification of Tumours. 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