{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:19:24Z","timestamp":1791332364978,"version":"4.3.1"},"reference-count":48,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2003,10,27]],"date-time":"2003-10-27T00:00:00Z","timestamp":1067212800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[2003,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Follicular dendritic cells (FDCs) in reactive germinal centres (GCs) show modulated expression of antigens indicative of step\u2010wise maturation from more undifferentiated stroma. The present study compared the expression of FDC markers CD21, CD23, CD35, and chemokine CXCL13 and the stromal markers low\u2010affinity nerve growth factor receptor (LNGFR) and CNA.42 in 35 follicular lymphoma (FL) cases with reactive lymphoic tissue. CXCL13 was expressed by follicular stroma in all FLs but most cases showed either partial (11\/35 cases, 31%) or complete (10\/35 cases, 29%) absence of other FDC antigens, most commonly CD23, followed by CD21 and CD35, with variable patterns of LNGFR and CNA.42 immunostaining. Only a minority of FL cases (14\/35, 40%) showed stroma that resembled mature FDCs (CD23+, CD21+, CD35+) and these tumours were always associated with numerous intrafollicular T\u2010cells, similar to reactive GCs. In the 25 FL cases that had identifiable extrafollicular tumour cells, the immunophenotype of follicular stroma showed the same variability but the extrafollicular stroma showed an absence of FDC markers, with the exception of frequent strong LNGFR staining. Stromal phenotypic changes in FL were not correlated with mean follicle size, percentage of diffuse growth, tumour mitotic rate or the proliferation index as determined by PCNA immunostaining. Serial biopsy specimens analysed in a subset of 15 patients showed either a stable stromal phenotype (seven cases, 47%) or loss of FDC antigens in tumour\u2010associated stroma over time (seven cases, 47%). The GC\u2010like subset of FLs, having both abundant intrafollicular T\u2010cells and fully differentiated CD23+ FDCs, comprises a minority of FL cases that likely have different growth requirements from FLs that lack these features. The pattern of FDC antigen loss in stroma of FL is a readily assessable biological feature that appears independent of architectural growth pattern and may serve as a useful surrogate marker of tumour progression. Copyright \u00a9 2003 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/path.1478","type":"journal-article","created":{"date-parts":[[2003,10,28]],"date-time":"2003-10-28T03:00:42Z","timestamp":1067310042000},"page":"404-412","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Germinal centre\u2010like versus undifferentiated stromal immunophenotypes in follicular lymphoma"],"prefix":"10.1002","volume":"201","author":[{"given":"Kong\u2010Chao","family":"Chang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuelin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L Jeffrey","family":"Medeiros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,10,27]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(199910)189:2<147::AID-PATH433>3.0.CO;2-8"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65165-6"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65179-6"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.9.3376"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0609.2000.90147.x"},{"key":"e_1_2_6_7_2","first-page":"155","article-title":"VLA\u20104\u2010dependent adhesion in follicular non\u2010Hodgkin's lymphomas","volume":"9","author":"Ishii G","year":"1995","journal-title":"Hematol Pathol"},{"key":"e_1_2_6_8_2","first-page":"496","article-title":"Expression of lymphocyte homing receptor antigen in non\u2010Hodgkin's lymphoma","volume":"130","author":"Picker LJ","year":"1988","journal-title":"Am J Pathol"},{"key":"e_1_2_6_9_2","first-page":"1","article-title":"Alterations in fascin\u2010expressing germinal center dendritic cells in neoplastic follicles of B\u2010cell lymphomas","volume":"11","author":"Said JW","year":"1998","journal-title":"Mod Pathol"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(89)90176-7"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197803022980903"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(01)00215-1"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/77401"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1155\/2001\/79823"},{"key":"e_1_2_6_15_2","first-page":"1108","article-title":"Microarray transcriptional cytokine analysis of cultured stromal cells (nodal fibroblastic reticulum cells and dermal fibroblasts) reveals tissue\u2010 and time in culture\u2010dependent responses","volume":"82","author":"Vega F","year":"2002","journal-title":"Lab Invest"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/25630"},{"key":"e_1_2_6_17_2","first-page":"959","article-title":"Dendritic reticulum cell immunoreactivity for low\u2010affinity nerve growth factor receptor in malignant lymphomas","volume":"9","author":"Dorfman DM","year":"1996","journal-title":"Mod Pathol"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/00022744-200106000-00003"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(200006)191:2<217::AID-PATH586>3.0.CO;2-6"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/00125480-200203000-00004"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200006000-00010"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/112.1.101"},{"key":"e_1_2_6_23_2","first-page":"162","volume-title":"World Health Organization Classification of Tumours. 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