{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T03:34:32Z","timestamp":1772595272337,"version":"3.50.1"},"reference-count":47,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2003,11,27]],"date-time":"2003-11-27T00:00:00Z","timestamp":1069891200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Yorkshire Cancer Research"},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"crossref","award":["ICA4-CT-1999-10010"],"award-info":[{"award-number":["ICA4-CT-1999-10010"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[2004,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Experimental infection with <jats:italic>Helicobacter pylori<\/jats:italic> in Mongolian gerbils results in chronic gastritis and gastric cancer. To investigate epithelial cell proliferation, apoptosis, and mucosal cytokine responses in gastritis, Mongolian gerbils were infected with the <jats:italic>H pylori<\/jats:italic> SS1 strain. At 4 weeks post\u2010infection, gastritis was predominantly within the antrum, but extended to the corpus in approximately 50% of gerbils by 36 weeks. Epithelial cell proliferation and apoptosis in glandular epithelial cells were increased with infection. Antral cell proliferation, but not apoptosis, correlated significantly with gastric inflammation. In female gerbils, <jats:italic>H pylori<\/jats:italic> significantly increased expression of transcripts for <jats:italic>IFN\u2010\u03b3<\/jats:italic> and <jats:italic>IL\u201012p40<\/jats:italic>, but not <jats:italic>TGF\u2010\u03b2<\/jats:italic> or <jats:italic>IL\u201010<\/jats:italic>, in the gastric mucosa. Significantly reduced <jats:italic>IFN\u2010\u03b3<\/jats:italic> and <jats:italic>IL\u201012p40<\/jats:italic> responses were observed in male gerbils infected with <jats:italic>H pylori<\/jats:italic>, but epithelial proliferative and apoptotic responses were comparable to those of females. These studies demonstrate that the female gerbil cytokine response to <jats:italic>H pylori<\/jats:italic> has a Th1 profile and that there are gender differences in the magnitude of the gastric cytokine responses to <jats:italic>H pylori<\/jats:italic>. The absence of a down\u2010regulatory cytokine response may account for the more severe gastritis observed with <jats:italic>H pylori<\/jats:italic> infection in gerbils than in mice. Copyright \u00a9 2004 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/path.1498","type":"journal-article","created":{"date-parts":[[2004,1,21]],"date-time":"2004-01-21T03:00:59Z","timestamp":1074654059000},"page":"197-207","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":76,"title":["Gastric mucosal cytokine and epithelial cell responses to <i>Helicobacter pylori<\/i> infection in Mongolian gerbils"],"prefix":"10.1002","volume":"202","author":[{"given":"Jean E","family":"Crabtree","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle","family":"Court","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed A","family":"Aboshkiwa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony HT","family":"Jeremy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael F","family":"Dixon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip A","family":"Robinson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2003,11,27]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65343-6"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1080\/00365529850171990"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(98)70143-X"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2006.00743.x"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.52.6.797"},{"key":"e_1_2_6_7_2","first-page":"4255","article-title":"Development of Helicobacter pylori\u2010induced gastric carcinoma in Mongolian gerbils","volume":"58","author":"Honda S","year":"1998","journal-title":"Cancer Res"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1086\/338772"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI11450"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/89.12.863"},{"key":"e_1_2_6_11_2","first-page":"1406","article-title":"Increased gastric epithelial cell apoptosis associated with colonisation with cagA+ H pylori strains","volume":"61","author":"Moss SF","year":"2001","journal-title":"Cancer Res"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1996.v110.pm8536852"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(98)70581-5"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1422"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(00)70413-6"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1013219621422"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1086\/344321"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.163.3.1490"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.165.2.1022"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/1521-4141(200102)31:2<396::AID-IMMU396>3.0.CO;2-Y"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1083-4389.2002.00071.x"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0928-8244(02)00464-9"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0923-2508(96)84023-X"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.53.4.318"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/cdli.3.1.66-72.1996"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1006\/cyto.2001.0866"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.48.6.765"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1086\/338191"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(97)70155-0"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.8.5056-5063.2001"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0047-6374(01)00323-2"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(98)70531-1"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(00)70213-7"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.156.12.4729"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)00070-4"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.52.9.658"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.7.4163-4166.2003"},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.2.900"},{"key":"e_1_2_6_39_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.70.9.5148-5157.2002"},{"key":"e_1_2_6_40_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.10.5369"},{"key":"e_1_2_6_41_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.162.9.5561"},{"key":"e_1_2_6_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(03)00406-2"},{"key":"e_1_2_6_43_2","first-page":"942","article-title":"Helicobacter pylori\u2010associated gastric cancer in INS\u2010GAS mice is gender specific","volume":"63","author":"Fox JG","year":"2003","journal-title":"Cancer Res"},{"key":"e_1_2_6_44_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00538.2001"},{"key":"e_1_2_6_45_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20012076"},{"key":"e_1_2_6_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0047-6374(03)00025-3"},{"key":"e_1_2_6_47_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M006809200"},{"key":"e_1_2_6_48_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.52.8.1102"}],"container-title":["The Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpath.1498","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpath.1498","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/path.1498","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T09:49:14Z","timestamp":1761040154000},"score":1,"resource":{"primary":{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/10.1002\/path.1498"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,11,27]]},"references-count":47,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2004,2]]}},"alternative-id":["10.1002\/path.1498"],"URL":"https:\/\/doi.org\/10.1002\/path.1498","archive":["Portico"],"relation":{},"ISSN":["0022-3417","1096-9896"],"issn-type":[{"value":"0022-3417","type":"print"},{"value":"1096-9896","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,11,27]]},"assertion":[{"value":"2003-08-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2003-10-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2003-11-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}