{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T07:48:54Z","timestamp":1791100134800,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,1,27]],"date-time":"2004-01-27T00:00:00Z","timestamp":1075161600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[2004,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Degradation of the extracellular matrix by matrix metalloproteinases (MMPs) is a crucial step in tumour invasion and metastasis. In human carcinomas, tumour cell\u2013fibroblast interactions (TFIs) have been demonstrated to play a role in the up\u2010regulation of MMP levels in tumours, and emmprin is a surface molecule on tumour cells that stimulates nearby fibroblasts to produce MMP\u20101, 2, and 3. T\u2010cell lymphomas frequently show extranodal organ involvement and skin invasion, but a role for TFIs in their invasion has not been examined in detail. This study investigated TFIs in T\u2010cell lymphomas with special reference to emmprin expression and MMP production. Immunohistochemically, only germinal centre cells and some histiocytes expressed emmprin in non\u2010neoplastic lymph nodes (ten cases), while all T\u2010cell lymphomas [14 cases of adult T\u2010cell leukaemia\/lymphoma (ATLL), six cases of lymphoblastic lymphoma, seven cases of anaplastic large cell lymphoma, and nine cases of angio\u2010immunoblastic T\u2010cell lymphoma] expressed emmprin strongly and diffusely. FACS analysis of peripheral blood from normal individuals revealed that small fractions of B\u2010cells, T\u2010cells, and monocytes expressed emmprin, whereas emmprin\u2010expressing T\u2010cells were much increased in number, and expressed this protein to a higher level, in ATLL patients.\n                    <jats:italic>In vitro<\/jats:italic>\n                    co\u2010cultures of emmprin\u2010positive HTLV\u20101\u2010transformed lymphocytes (MT\u20102) and emmprin\u2010negative human fibroblasts enhanced the production of pro\u2010MMP\u20102 (gelatinase A) and active MMP\u20102, compared with cultures of either cell type alone. This stimulation was inhibited by an activity\u2010blocking peptide against emmprin. Moreover, in histopathological sections from patients with ATL skin involvement, MMP\u20102 was demonstrated in fibroblasts around infiltrating ATL cells, but not in fibroblasts in non\u2010diseased areas. In conclusion, emmprin is overexpressed by T\u2010lymphoma cells, when compared with normal counterparts, and facilitates MMP\u20102 production via interactions with fibroblasts, which could play a role in stromal invasion by lymphoma cells. Copyright \u00a9 2004 Pathological Society of Great Britain and Ireland. Published by John Wiley &amp; Sons, Ltd.\n                  <\/jats:p>","DOI":"10.1002\/path.1518","type":"journal-article","created":{"date-parts":[[2004,2,26]],"date-time":"2004-02-26T15:24:06Z","timestamp":1077809046000},"page":"341-351","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":76,"title":["Emmprin, a cell surface inducer of matrix metalloproteinases (MMPs), is expressed in T\u2010cell lymphomas"],"prefix":"10.1002","volume":"202","author":[{"given":"Kazuki","family":"Nabeshima","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junji","family":"Suzumiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuyuki","family":"Nagano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Ohshima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan P","family":"Toole","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuo","family":"Tamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Iwasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Kikuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,2,16]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90642-C"},{"key":"e_1_2_6_3_2","first-page":"434","article-title":"The human tumor cell\u2010derived collagenase stimulatory factor (renamed EMMPRIN) is a member of the immunoglobulin superfamily","volume":"55","author":"Biswas C","year":"1995","journal-title":"Cancer Res"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.107.2.477"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/348699a0"},{"key":"e_1_2_6_6_2","first-page":"389","article-title":"Stromal expression of 72kDa type IV collagenase (MMP\u20102) and TIMP\u20102 mRNAs in colorectal neoplasia","volume":"141","author":"Poulsom R","year":"1992","journal-title":"Am J Pathol"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.7.2730"},{"key":"e_1_2_6_8_2","first-page":"273","article-title":"Expression of most matrix metalloproteinase family members in breast cancer represents a tumor\u2010induced host response","volume":"149","author":"Heppner KJ","year":"1996","journal-title":"Am J Pathol"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910550105"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/002215549704500508"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(20000201)85:3<347::AID-IJC9>3.0.CO;2-#"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0215(20001001)88:1<21::AID-IJC4>3.0.CO;2-S"},{"key":"e_1_2_6_13_2","first-page":"1983","article-title":"EMMPRIN (CD174) is expressed in Hodgkin's lymphoma and anaplastic large cell lymphoma. 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