{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T14:34:17Z","timestamp":1780410857196,"version":"3.54.1"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,3,18]],"date-time":"2004-03-18T00:00:00Z","timestamp":1079568000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[2004,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Extracellular matrix proteins have a prominent role in both ontogenesis and fibrogenesis in the human lung. The aim of this study was to analyse the expression of newly formed precursor proteins and mRNA of collagen types I and III in developing human lung tissues from 12 to 40 weeks of gestation, and also in neonatal disorders such as respiratory distress syndrome (RDS) and bronchopulmonary dysplasia (BPD). Lung tissues were obtained at autopsy from 60 non\u2010malformed cases. All tissues were analysed by immunohistochemistry and 24 were also investigated by mRNA <jats:italic>in situ<\/jats:italic> hybridization. The precursor proteins and mRNA of both collagens were expressed in abundance in pulmonary arteries and veins during all developmental periods. In RDS and BPD, precursor proteins and mRNAs of both collagen types were increased within alveolar walls. The cells in these locations showed \u03b1\u2010smooth muscle actin, vimentin, and variable desmin immunoreactivity. Collagen I and III precursor proteins and mRNA were also observed in pleura, bronchi, bronchioles, and around chondrocytes during all developmental periods and in diseased lung. In conclusion, collagens I and III were expressed in a similar way in and around various cell types in the developing lung and their expression was increased within alveolar walls in RDS and BPD. Myofibroblast\u2010type cells appeared to produce mRNA for both types of collagen in alveoli. Copyright \u00a9 2004 Pathological Society of Great Britain and Ireland. Published by John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/path.1547","type":"journal-article","created":{"date-parts":[[2004,4,5]],"date-time":"2004-04-05T03:01:09Z","timestamp":1081134069000},"page":"567-574","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Type I and III collagen protein precursors and mRNA in the developing human lung"],"prefix":"10.1002","volume":"203","author":[{"given":"Riitta","family":"Kaarteenaho\u2010Wiik","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paavo","family":"P\u00e4\u00e4kk\u00f6","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riitta","family":"Herva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juha","family":"Risteli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ylermi","family":"Soini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,3,18]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196702162760701"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0095-5108(18)30444-5"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.87.5.587"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.15.6642"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-0496(199707)24:1<22::AID-PPUL4>3.0.CO;2-L"},{"key":"e_1_2_6_7_2","first-page":"399","article-title":"Ultrastructural distribution of fibronectin in normal and fibrotic lung","volume":"52","author":"Torikata C","year":"1985","journal-title":"Lab Invest"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s100249900068"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb.25.3.4460"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/002215540205000313"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.154.2.8756830"},{"key":"e_1_2_6_12_2","first-page":"15 623","article-title":"Global analysis of gene expression in pulmonary fibrosis reveals distinct programs regulating lung inflammation and fibrosis","volume":"95","author":"Kaminski N","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.111.4.766"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.163.7.2011060"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.89.5.969"},{"key":"e_1_2_6_16_2","first-page":"16","volume-title":"Perspectives in Pediatric Pathology","author":"Rosan CR","year":"1975"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(98)90280-5"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711680112"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/34.4.715"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/42.6.947"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2017680"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00413250"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/16.1.349"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb\/7.3.325"},{"key":"e_1_2_6_25_2","first-page":"1257","article-title":"The roles of the myofibroblasts in the idiopathic pulmonary fibrosis","volume":"138","author":"Kuhn C","year":"1991","journal-title":"Am J Pathol"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.6.11.1644255"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)34351-5"},{"key":"e_1_2_6_28_2","first-page":"77","article-title":"Analysing connective tissue metabolites in human serum. 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