{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T18:49:08Z","timestamp":1762541348619,"version":"build-2065373602"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2004,7,8]],"date-time":"2004-07-08T00:00:00Z","timestamp":1089244800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[2004,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The present study has compared immunohistological marker expression profiles and genomic imbalances in seven African endemic Burkitt's lymphomas (eBLs) with those in ten European B\u2010cell lymphomas with <jats:italic>MYC<\/jats:italic> rearrangement as shown by fluorescence <jats:italic>in situ<\/jats:italic> hybridization (FISH) analysis. eBLs showed a typical histomorphology and a homogeneous immuno\u2010profile: CD10+, CD38+, CD77+, bcl\u20102\u2013, and IgM+. Epstein\u2013Barr virus (EBV) DNA was present in all cases. On comparative genomic hybridization (CGH), only three out of six eBLs showed imbalances (median number of imbalances = 2), with gains on chromosome 17 in two eBLs. The European lymphomas were all highly proliferating, with a Ki\u201067 index of at least 90%, and included seven with morphology typical of sporadic Burkitt's lymphoma (sBL) and three immunoblastic diffuse large B\u2010cell lymphomas with <jats:italic>MYC<\/jats:italic> rearrangement (<jats:italic>MYC<\/jats:italic>re+DLBCL). In contrast to eBL, the immuno\u2010profiles of the European lymphomas were less homogeneous and inconsistent for CD10, CD38, CD77, IgM and bcl\u20102 expression. EBV DNA was not detected. In five of seven sBLs, CGH showed a higher number of imbalances (median = 6), with recurrent gains on chromosome 1q (3\/7) and losses on 12q and 17p (2\/7), whereas all three <jats:italic>MYC<\/jats:italic>re+DLBCLs had fewer imbalances (median = 4), with gains on 17q in two of three lymphomas. It is concluded that eBL has a homogeneous immunohistology and few secondary genomic aberrations, whereas <jats:italic>MYC<\/jats:italic>\u2010rearranged and highly proliferating European B\u2010cell lymphomas are a heterogeneous group that includes sBL and a subgroup of diffuse large B\u2010cell lymphomas. Copyright \u00a9 2004 Pathological Society of Great Britain and Ireland. Published by John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/path.1596","type":"journal-article","created":{"date-parts":[[2004,7,8]],"date-time":"2004-07-08T14:05:58Z","timestamp":1089295558000},"page":"940-945","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Homogeneous immunophenotype and paucity of secondary genomic aberrations are distinctive features of endemic but not of sporadic Burkitt's lymphoma and diffuse large B\u2010cell lymphoma with <i>MYC<\/i> rearrangement"],"prefix":"10.1002","volume":"203","author":[{"given":"Thomas FE","family":"Barth","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silja","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Pawlita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reiner","family":"Siebert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josef U","family":"Rother","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gunhild","family":"Mechtersheimer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Kitinya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Bentz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"M\u00f6ller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,7,8]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_6_2_2","DOI":"10.1182\/blood.V93.3.1124"},{"doi-asserted-by":"publisher","key":"e_1_2_6_3_2","DOI":"10.1200\/JCO.1996.14.3.925"},{"key":"e_1_2_6_4_2","first-page":"181","volume-title":"Tumours of Haematopoietic and Lymphoid Tissues","author":"Diebold J","year":"2001"},{"doi-asserted-by":"publisher","key":"e_1_2_6_5_2","DOI":"10.1182\/blood.V79.12.3261.3261"},{"key":"e_1_2_6_6_2","first-page":"6547","article-title":"Mapping chromosomal breakpoints of Burkitt's t(8;14) translocations far upstream of c\u2010myc","volume":"52","author":"Joos S","year":"1992","journal-title":"Cancer Res"},{"doi-asserted-by":"publisher","key":"e_1_2_6_7_2","DOI":"10.1073\/pnas.83.9.2984"},{"doi-asserted-by":"publisher","key":"e_1_2_6_8_2","DOI":"10.1073\/pnas.79.24.7824"},{"doi-asserted-by":"publisher","key":"e_1_2_6_9_2","DOI":"10.1073\/pnas.79.24.7837"},{"doi-asserted-by":"publisher","key":"e_1_2_6_10_2","DOI":"10.1200\/JCO.2000.18.3.510"},{"doi-asserted-by":"publisher","key":"e_1_2_6_11_2","DOI":"10.1056\/NEJM198805263182106"},{"doi-asserted-by":"publisher","key":"e_1_2_6_12_2","DOI":"10.1097\/01.MP.0000019577.73786.64"},{"doi-asserted-by":"publisher","key":"e_1_2_6_13_2","DOI":"10.1182\/blood.V90.2.526"},{"doi-asserted-by":"publisher","key":"e_1_2_6_14_2","DOI":"10.1111\/j.1365-2141.1984.tb02913.x"},{"doi-asserted-by":"publisher","key":"e_1_2_6_15_2","DOI":"10.1002\/gcc.2870020211"},{"doi-asserted-by":"publisher","key":"e_1_2_6_16_2","DOI":"10.1038\/sj.leu.2403080"},{"doi-asserted-by":"publisher","key":"e_1_2_6_17_2","DOI":"10.1182\/blood.V69.4.1087.1087"},{"doi-asserted-by":"publisher","key":"e_1_2_6_18_2","DOI":"10.1016\/0076-6879(95)54024-5"},{"doi-asserted-by":"publisher","key":"e_1_2_6_19_2","DOI":"10.1002\/1098-2264(200007)28:3<353::AID-GCC15>3.0.CO;2-0"},{"doi-asserted-by":"publisher","key":"e_1_2_6_20_2","DOI":"10.1002\/ijc.10169"},{"doi-asserted-by":"publisher","key":"e_1_2_6_21_2","DOI":"10.1002\/(SICI)1098-2264(199811)23:3<220::AID-GCC3>3.0.CO;2-3"},{"doi-asserted-by":"publisher","key":"e_1_2_6_22_2","DOI":"10.1182\/blood.V91.3.984"},{"doi-asserted-by":"publisher","key":"e_1_2_6_23_2","DOI":"10.1182\/blood.V85.11.3223.bloodjournal85113223"},{"doi-asserted-by":"publisher","key":"e_1_2_6_24_2","DOI":"10.3109\/10428199409051664"},{"doi-asserted-by":"publisher","key":"e_1_2_6_25_2","DOI":"10.1182\/blood.V93.2.758"},{"doi-asserted-by":"publisher","key":"e_1_2_6_26_2","DOI":"10.1111\/j.1365-2141.1984.tb02913.x"},{"doi-asserted-by":"publisher","key":"e_1_2_6_27_2","DOI":"10.1034\/j.1600-0609.2003.00094.x"},{"doi-asserted-by":"publisher","key":"e_1_2_6_28_2","DOI":"10.1016\/S0002-9440(10)61686-0"},{"key":"e_1_2_6_29_2","first-page":"3114","article-title":"Clinicopathogenetic significance of chromosomal abnormalities in patients with blastic peripheral B\u2010cell lymphoma. 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