{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T06:22:18Z","timestamp":1790144538351,"version":"4.0.1"},"reference-count":55,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2004,11,10]],"date-time":"2004-11-10T00:00:00Z","timestamp":1100044800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[2004,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hodgkin\/Reed\u2013Sternberg (HRS) cells of classical Hodgkin's lymphoma (cHL) are thought to be derived from germinal centre B\u2010cells in almost all cases. However, expression profiling has revealed that HRS cells do not show a germinal centre B\u2010cell\u2010like phenotype. Although the nature of this aberrant phenotype and the underlying molecular mechanisms remain largely unknown, it has been reported that the activity of NOTCH1 plays an important role in the growth and survival of HRS cells. In some leukaemic cell lines, the effect of Notch signalling is mediated by the early transcription factor GATA\u20102. This and the fact that HRS cells lack expression of PU.1, which can repress <jats:italic>Gata\u20102<\/jats:italic>, led to an investigation of GATA\u20102 expression in HRS cells. GATA\u20102 expression was found in all the cHL\u2010derived cell lines studied, but not in a Burkitt lymphoma\u2010derived cell line. In addition, 50% of biopsies from patients with cHL contained GATA\u20102\u2010expressing HRS cells. In contrast, neither normal germinal centre B\u2010cells nor malignant cells of nodular lymphocyte\u2010predominant Hodgkin's lymphoma, Burkitt lymphoma or diffuse large B\u2010cell lymphoma expressed GATA\u20102. Thus, GATA\u20102 expression was found specifically in HRS cells of cHL, suggesting that GATA\u20102 is important in establishing the abnormal B\u2010cell phenotype of HRS cells. Copyright \u00a9 2004 Pathological Society of Great Britain and Ireland. Published by John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/path.1664","type":"journal-article","created":{"date-parts":[[2004,11,10]],"date-time":"2004-11-10T15:12:54Z","timestamp":1100099574000},"page":"538-545","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["The early transcription factor GATA\u20102 is expressed in classical Hodgkin's 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