{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T09:06:43Z","timestamp":1791104803162,"version":"4.1.0"},"reference-count":46,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,1,28]],"date-time":"2005-01-28T00:00:00Z","timestamp":1106870400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[2005,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Primary cutaneous marginal zone lymphomas (PCMZL) share histological and clinical characteristics with mucosa\u2010associated lymphoid tissue (MALT) lymphomas suggesting a common pathogenesis. A number of recurrent structural and numerical chromosomal aberrations have been described in MALT lymphoma, but their incidence in PCMZL is largely unknown, as is their relation with clinical and pathological data. In this study, the incidence of t(11;18)(q21;q21), t(1;14)(p22;q32), two different t(14;18)(q32;q21), involving either <jats:italic>IGH\/MALT1<\/jats:italic> or <jats:italic>IGH\/BCL2<\/jats:italic>, and numerical aberrations of chromosomes 3, 7, 12 and 18 were analysed in 12 patients with PCMZL, with follow\u2010up of up to 10 years. Nuclei were isolated from paraffin wax sections for dual\u2010colour interphase fluorescence <jats:italic>in situ<\/jats:italic> hybridization (FISH) using various probe sets either flanking or spanning the involved genes. T(14;18)(q32;q21), with breakpoints in <jats:italic>IGH<\/jats:italic> and <jats:italic>MALT1<\/jats:italic>, was found in three cases. All three had partly monocytoid histological appearances and lacked blastic transformation. An additional trisomy of chromosome 3 was detected in one of these cases. Trisomy 18 was present in two lymphomas without monocytoid morphology. No definite correlation was seen with any clinical feature, including <jats:italic>Borrelia<\/jats:italic> serology. Neither t(11;18)(q21;q21), nor t(1;14)(p22;q32) or any other translocation involving <jats:italic>IGH, BCL10, MALT1, BCL2<\/jats:italic> and <jats:italic>API2<\/jats:italic>, amplification or deletion of chromosomal region 11q21, 18q21, 1p22, and 14q32 was detected. These results indicate that a subgroup of PCMZL with partly monocytoid morphology is genetically related to MZL at other extranodal sites. Copyright \u00a9 2005 Pathological Society of Great Britain and Ireland. 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