{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:46:15Z","timestamp":1761007575190,"version":"build-2065373602"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,6,15]],"date-time":"2005-06-15T00:00:00Z","timestamp":1118793600000},"content-version":"vor","delay-in-days":8780,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[1981,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Methods used in the study of human mononuclear phagocytes in vitro were applied to surgical specimens from 49 patients with non\u2010Hodgkin lymphomas and eight patients with hairy cell leukaemia.<\/jats:p><jats:p>Two of the tumours (both classified as \u201ctrue histiocytic\u201d neoplasms by the Kiel criteria) were distinguished by the presence of atypical macrophages in the <jats:italic>in vitro<\/jats:italic> system. In one the atypical cells were adherent; In the other example they were non\u2010adherent. These tumours were the only examples of mononuclear phagocyte neoplasia identified in this series. All the remaining 47 cases of non\u2010Hodgkin lymphoma were judged to be of lymphoid origin.<\/jats:p><jats:p>While initial observations on hairy cell leukaemia\u2010derived spleen cells suggested macrophage neoplasia, this impression does not stand up to more detailed analysis. The findings are more in keeping with a B lymphoid cell lineage.<\/jats:p><jats:p>In hairy cell leukaemias and low grade lymphoma the proportion of macrophages per gram weight of tissue is diminished. This suggests a deficiency of macrophage functional activity compared with normal; the nature of this defect is not clear.<\/jats:p>","DOI":"10.1002\/path.1711340203","type":"journal-article","created":{"date-parts":[[2005,6,21]],"date-time":"2005-06-21T14:37:30Z","timestamp":1119364650000},"page":"117-132","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Macrophages in non\u2010hodgkin lymphomas and hairy cell leukaemia"],"prefix":"10.1002","volume":"134","author":[{"given":"D. R.","family":"Katz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,15]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711220104"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(74)91786-3"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V13.7.609.609"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197405)33:5<1399::AID-CNCR2820330526>3.0.CO;2-E"},{"key":"e_1_2_1_6_1","first-page":"601","article-title":"Histochemical comparison of naphthol\u2010AS\u2010phosphates for the demonstration of phosphatases","volume":"20","author":"Burstone M. S.","year":"1958","journal-title":"J.N.C.I."},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1974.tb00446.x"},{"key":"e_1_2_1_8_1","unstructured":"Dacie J. V. andLewis S. M.1975.Practical Haematology 5th. Edition Churchill."},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(74)91177-5"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(75)90228-4"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.139.5.1077"},{"key":"e_1_2_1_12_1","first-page":"406","article-title":"Classification of non\u2010Hodgkin's lymphomas","author":"Gerard\u2010Marchant R.","year":"1974","journal-title":"Lancet"},{"key":"e_1_2_1_13_1","first-page":"244","article-title":"Free immunoglobulin light chain synthesis by neoplastic cells in leukaemic reticuloendotheliosis","volume":"31","author":"Gordon J.","year":"1978","journal-title":"Clin. Exp. Immunol."},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/14.4.291"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1979.137"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.1958.0043"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(74)90775-X"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197304)31:4<806::AID-CNCR2820310408>3.0.CO;2-1"},{"key":"e_1_2_1_19_1","first-page":"145","article-title":"The macrophage in Hodgkin's disease","volume":"133","author":"Katz D. R.","year":"1981","journal-title":"J. Palhol."},{"volume-title":"Handbuch der speziellen pathologischen anatomie und histologie","year":"1978","author":"Lennert K.","key":"e_1_2_1_20_1"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/20.12.1049"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197410)34:8 <1488::AID-CNCR2820340822>3.0.CO;2-C"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910190309"},{"key":"e_1_2_1_24_1","first-page":"259","article-title":"Les reticulosarcomes et les reticuloendotheliosarcomes de la moelle osseuse","volume":"17","author":"Oberling C.","year":"1928","journal-title":"Bull, de I'Assoc. I'etude du Cancer"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V40.6.777.777"},{"key":"e_1_2_1_26_1","first-page":"440","article-title":"The mutual clonal origin of the lymphoplasmocytic and lymphoma cell in alpha chain disease","volume":"27","author":"Ramot B.","year":"1977","journal-title":"Clin. Exp. Immunol."},{"key":"e_1_2_1_27_1","unstructured":"Rappaport H.1966.Tumours of the haematopoietic system. Atlas of tumour pathology Sect. III Fasc. 8. Armed Forces Institute of Pathology."},{"key":"e_1_2_1_28_1","first-page":"182","article-title":"Leukaemic reticuloendotheliosis","volume":"295","author":"Seshadri R. S.","year":"1976","journal-title":"NEJM"}],"container-title":["The Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpath.1711340203","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/path.1711340203","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T14:19:29Z","timestamp":1760969969000},"score":1,"resource":{"primary":{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/10.1002\/path.1711340203"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,6]]},"references-count":27,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1981,6]]}},"alternative-id":["10.1002\/path.1711340203"],"URL":"https:\/\/doi.org\/10.1002\/path.1711340203","archive":["Portico"],"relation":{},"ISSN":["0022-3417","1096-9896"],"issn-type":[{"type":"print","value":"0022-3417"},{"type":"electronic","value":"1096-9896"}],"subject":[],"published":{"date-parts":[[1981,6]]},"assertion":[{"value":"1980-07-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2005-06-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}