{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T10:29:14Z","timestamp":1761647354214,"version":"build-2065373602"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,6,16]],"date-time":"2005-06-16T00:00:00Z","timestamp":1118880000000},"content-version":"vor","delay-in-days":8689,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[1981,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Sudden death in cattle, especially calves, is a common problem of farm practice. Some cases are associated with significant cardiac lesions; in others, although necropsy suggests cardiac failure to be the cause of death, histological examination of H &amp; E sections fails to demonstrate conclusively the site and nature of the lesion. We have studied 26 animals which died suddenly and in which the only pathological abnormalities detected were definite or equivocal myocardial necrosis. Three types of necrosis were identified: myodegeneration, contraction band necrosis and coagulation necrosis. Vacuolation of myocytes occurred in control hearts only in the sub\u2010endocardial myocardium, but was found more extensively in diseased hearts. Paraffin sections of myocardium stained by von K\u00f2ssa's method or by haematoxylin\u2010basic fuchsin\u2010picric acid improved the detection of myocardial necrosis. Some myocardium was examined by electron microscopy which detected early myocardial necrosis in some equivocal cases and defined the nature of the lesion in more advanced cases. Early changes were an increase in the number of type A mitochondrial inclusions which did not contain significant quantities of calcium but which increased in number after death, albeit to a lesser degree, even in control material. This was followed by deposition of electron\u2010dense granules and spicules (Type B inclusions) and totally electron\u2010opaque mitochondria in association with contraction band necrosis. X\u2010ray microanalysis showed type B inclusions and electron\u2010opaque mitochondria to have peaks for calcium. It is suggested that myocardial cell death in animals having such lesions resulted from mitochondrial calcium overload. The findings are discussed in relation to nutritional myopathies of ruminants and human myocardial disease associated with sudden death, and to experimental myocardial ischaemia.<\/jats:p>","DOI":"10.1002\/path.1711350104","type":"journal-article","created":{"date-parts":[[2005,6,21]],"date-time":"2005-06-21T14:38:55Z","timestamp":1119364735000},"page":"19-38","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Sudden death and myocardial necrosis in cattle"],"prefix":"10.1002","volume":"135","author":[{"given":"R.","family":"Bradley","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. M.","family":"Markson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Bailey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,16]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9975(78)90022-1"},{"key":"e_1_2_1_3_1","first-page":"243","article-title":"Changes of cardiac and skeletal muscle in pigs following transport stress. An electron microscopic study","volume":"17","author":"Bergmann V.","year":"1979","journal-title":"Expl. Path."},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.103.11.239"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"918","DOI":"10.2460\/javma.1977.171.09.918","article-title":"Capture myopathy in pronghorns in Alberta, Canada","volume":"171","author":"Chalmers G. A.","year":"1977","journal-title":"J. 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