{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T14:12:25Z","timestamp":1760969545416,"version":"build-2065373602"},"reference-count":16,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,6,16]],"date-time":"2005-06-16T00:00:00Z","timestamp":1118880000000},"content-version":"vor","delay-in-days":8659,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[1981,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Gout is principally a disease of middle\u2010aged men. There has been a lot of discussion over the cause of the renal lesion, whether it is age, hypertension or crystal induced, as single factors or in combination.<\/jats:p><jats:p>We have recently been able to study renal biopsies from three related young women with an hereditary gout, and another girl with 2,8\u2010dihydroxyadenine crystal nephropathy. All were normotensive. These findings were compared with the findings of a crystal\u2010induced nephropathy in pigs. In the renal biopsies many stages of acute and chronic nephritis were found which were similar to the crystal nephropathy in the pigs. We concluded that the cause of the original lesion in the women was crystal deposition in the tubules, that crystals were not necessary to keep a non\u2010specific nephritis active and that age and hypertension need not be contributory factors.<\/jats:p>","DOI":"10.1002\/path.1711350206","type":"journal-article","created":{"date-parts":[[2005,6,21]],"date-time":"2005-06-21T14:38:58Z","timestamp":1119364738000},"page":"159-168","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Uric acid crystal\u2010induced nephropathy: Evidence for a specific renal lesion in a gouty family"],"prefix":"10.1002","volume":"135","author":[{"given":"D. A.","family":"Farebrother","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. R.","family":"Pincott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. A.","family":"Simmons","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. J.","family":"Warren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. J.","family":"Dillon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. S.","family":"Cameron","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,16]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_1_2_1","DOI":"10.1056\/NEJM195008312430901"},{"doi-asserted-by":"publisher","key":"e_1_2_1_3_1","DOI":"10.1002\/path.1711090304"},{"doi-asserted-by":"publisher","key":"e_1_2_1_4_1","DOI":"10.1038\/ki.1975.81"},{"key":"e_1_2_1_5_1","first-page":"523","volume-title":"Purine metabolism in man","author":"Farebrother D. A.","year":"1973"},{"key":"e_1_2_1_6_1","first-page":"243","article-title":"Experimental crystal nephropathy (one year study in the pig)","volume":"4","author":"Farebrother D. A.","year":"1975","journal-title":"Clinical Nephropathy"},{"doi-asserted-by":"publisher","key":"e_1_2_1_7_1","DOI":"10.1177\/095952874803100109"},{"doi-asserted-by":"publisher","key":"e_1_2_1_8_1","DOI":"10.1136\/bmj.1.5238.1502"},{"key":"e_1_2_1_9_1","first-page":"966","volume-title":"Pathology of the kidney","author":"Heptinstall R. H.","year":"1974"},{"unstructured":"Leumann E. P. andWegmann W.1972.Hereditary nephropathy with hyperuricaemia. Abstracts. 6th meeting of the European Society of Paediatric Nephrology Dublin.","key":"e_1_2_1_10_1"},{"key":"e_1_2_1_11_1","first-page":"138","volume-title":"Aktuelle diagnostick von Nierenerk\u2010rankungen","author":"Meyer V. D.","year":"1974"},{"key":"e_1_2_1_12_1","first-page":"15","volume-title":"Purine metabolism in man, III ed.","author":"Simmonds H. A.","year":"1979"},{"key":"e_1_2_1_13_1","first-page":"176","article-title":"Familial gout and renal failure in young women","volume":"14","author":"Simmonds H. A.","year":"1980","journal-title":"Clinical Nephrology"},{"doi-asserted-by":"publisher","key":"e_1_2_1_14_1","DOI":"10.1097\/00005792-196012000-00001"},{"doi-asserted-by":"publisher","key":"e_1_2_1_15_1","DOI":"10.1136\/jcp.24.4.354"},{"doi-asserted-by":"publisher","key":"e_1_2_1_16_1","DOI":"10.1136\/adc.56.9.699"},{"doi-asserted-by":"publisher","key":"e_1_2_1_17_1","DOI":"10.1016\/0049-0172(75)90014-1"}],"container-title":["The Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpath.1711350206","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/path.1711350206","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T13:32:09Z","timestamp":1760967129000},"score":1,"resource":{"primary":{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/10.1002\/path.1711350206"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,10]]},"references-count":16,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1981,10]]}},"alternative-id":["10.1002\/path.1711350206"],"URL":"https:\/\/doi.org\/10.1002\/path.1711350206","archive":["Portico"],"relation":{},"ISSN":["0022-3417","1096-9896"],"issn-type":[{"type":"print","value":"0022-3417"},{"type":"electronic","value":"1096-9896"}],"subject":[],"published":{"date-parts":[[1981,10]]},"assertion":[{"value":"1980-11-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2005-06-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}