{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:40:00Z","timestamp":1761007200228,"version":"build-2065373602"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,6,16]],"date-time":"2005-06-16T00:00:00Z","timestamp":1118880000000},"content-version":"vor","delay-in-days":8416,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[1982,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The epithelioid cell granuloma in high resistant tuberculoid (TT) leprosy was contrasted with the pure macrophage granuloma of anergic lepromatous leprosy (LL) by evaluating various immunological factors operating in these lesions. The immunoperoxidase technique using antisera to immunoglobulin IgG, IgM, complement C<jats:sub>3<\/jats:sub>, C<jats:sub>3<\/jats:sub>d and C<jats:sub>1<\/jats:sub>q and other products of macrophage secretion, lysozyme, plasminogen, a<jats:sub>1<\/jats:sub> antitrypsin and C\u2010reactive protein and of la antigens revealed peak levels in tissues of most of these factors in both types of granuloma. The tuberculoid response was linked to low antigenic load and Ia\u2010like antigen and the lepromatous response was secondary to a high antigenic load in the absence of Ia antigen.<\/jats:p><jats:p>Complement and other mediators were found intracellularly in both tuberculoid and lepromatous granulomas, but extracellilarly only in tuberculoid lesions. This may indicate local hypersensitivity in the tuberculoid granuloma. It is suggested that the mediators in LL macrophages remain bound to the lipids of mycobacterial degeneration in the phagocytic vacuole.<\/jats:p><jats:p>Secretory cells were differently sited in the two types of granulomas: peripheral in epithelioid cell lesions and central around capillaries over the whole lesion in pure macrophage granulomas of LL. In tuberculoid leprosy many of the central vessels in the granuloma were obliterated.<\/jats:p><jats:p>C<jats:sub>1<\/jats:sub>q was found in fibroblasts. However, the marked absence of fibrosis in any of the lesions of leprosy, except following severe reactions, casts some doubt on the link which has been postulated between epithelioid cells and fibroblasts as an explanation of fibrosis in granulomas.<\/jats:p>","DOI":"10.1002\/path.1711370208","type":"journal-article","created":{"date-parts":[[2005,6,21]],"date-time":"2005-06-21T14:42:46Z","timestamp":1119364966000},"page":"149-157","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["An immunoperoxidase study of immunological factors in high immune and low resistance granulomas in leprosy"],"prefix":"10.1002","volume":"137","author":[{"given":"Marian J.","family":"Ridley","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deborah","family":"Russell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,16]]},"reference":[{"volume-title":"The pathology of granulomas","year":"1980","author":"Adams D. 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