{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T10:55:25Z","timestamp":1761216925725,"version":"build-2065373602"},"reference-count":19,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,6,16]],"date-time":"2005-06-16T00:00:00Z","timestamp":1118880000000},"content-version":"vor","delay-in-days":8355,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[1982,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The area cerebrovasculosa has been examined in 35 anencephalic fetuses and coronal sections prepared in 15 cases. A bilaterally symmetrical cystic mass is found covering the anterior and middle cranial fossae. The mass is generally walled with glial tissue, partially lined with ependyma and filled with abnormally vascular choroid plexus. The coverings of the cyst are conspicuously vascular and the overlying squamous epithelium is in continuity with hairy skin at the margins of the lesion. The posterior cranial fossa contains a variable quantity of medulla oblongata which has no connection with the cystic mass. The medulla and cervical cord are more nearly normal in that minority of cases with an intact foramen magnum. The degree of hindbrain development is correlated with the previously reported presence of heterotopic glial tissue in the spinal subarachnoid space of some anencephalic fetuses (Bell, Gordon and Maloney, 1981; Bell, 1981, in press).<\/jats:p><jats:p>These findings have led us to reject the widely accepted view that the area cerebrovasculosa is totally disorganised, and that anencephaly is characterised by absence of the forebrain.<\/jats:p>","DOI":"10.1002\/path.1711370406","type":"journal-article","created":{"date-parts":[[2005,6,21]],"date-time":"2005-06-21T14:43:04Z","timestamp":1119364984000},"page":"315-328","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Studies on the area cerebrovasculosa of anencephalic fetuses"],"prefix":"10.1002","volume":"137","author":[{"given":"Jeanne E.","family":"Bell","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert J. L.","family":"Green","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,16]]},"reference":[{"key":"e_1_2_1_2_1","unstructured":"Bell Jeanne E.1981.The pathology of central nervous system defects in human fetuses of different gestational ages. In Advances in the study of birth defects: central nervous system and craniofacial malformations edited by T. V. N. Persaud Lancaster vol. 7 in press."},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711330205"},{"key":"e_1_2_1_4_1","first-page":"471","article-title":"Forebrain in human anencephaly","volume":"142","author":"Chaurasia B. D.","year":"1977","journal-title":"Anat. Anz."},{"key":"e_1_2_1_5_1","first-page":"257","article-title":"Contribution to the study of spina bifida. encephalocele. and anencephalus","volume":"17","author":"Cleland J.","year":"1883","journal-title":"J. Anat. Physiol."},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1700690116"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1090360403"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000140997"},{"key":"e_1_2_1_9_1","first-page":"12","article-title":"Report on an anencephalic embryo","volume":"56","author":"Frazer J. E.","year":"1921","journal-title":"J. Anat."},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00428230"},{"key":"e_1_2_1_11_1","doi-asserted-by":"crossref","unstructured":"Giroud A.1960.Causes and morphogenesis of anencephaly.Causes and morphogenesis of anencephalyCongenital malformations: Ciba Foundation Symposium edited by G. E. W. Wolstenholme and C. M. O'Connor London p.199.","DOI":"10.1002\/9780470715277.ch10"},{"key":"e_1_2_1_12_1","first-page":"527","article-title":"Anencephaly: a review and interpretation in terms of modern experimental embryology","volume":"31","author":"Hanaway J.","year":"1970","journal-title":"Dis. Nerv. Syst."},{"key":"e_1_2_1_13_1","unstructured":"Morison J. E.1970.Foetal and neonatal pathology 3rd. ed. London p.468."},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-198140010-00003"},{"key":"e_1_2_1_15_1","unstructured":"Thomas A. andde Ajuriaguerra J.1959.\u00c9tude anatomoclinique de I'anenc\u00e9phalie.\u00c9tude anatomoclinique de I'anenc\u00e9phalieMalformations Cong\u00e9nitales du Cerveau edited by G. Heuyer M. Feld and J. Gruner Paris p.207."},{"key":"e_1_2_1_16_1","unstructured":"Urich H.1976.Malformations of the nervous system perinatal damage and related conditions in early life.Malformations of the nervous system perinatal damage and related conditions in early lifeGreenfield's neuropathology 3rd. ed. edited by W. Black wood and J. A. N. Corsellis London p.368."},{"key":"e_1_2_1_17_1","first-page":"147","article-title":"Anencephaly and rachischisis. Case description, pathology and aetiology","volume":"54","author":"Van Der Zwan A.","year":"1951","journal-title":"Folia Psych. Neurol. Neurochir. Neerl."},{"key":"e_1_2_1_18_1","first-page":"701","article-title":"Anomalies of major cerebral arteries associated with congenital malformations of the brain. With special reference to the pathogenesis of anencephaly","volume":"28","author":"Vogel F. S.","year":"1952","journal-title":"Am. J. Path."},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1091110405"},{"key":"e_1_2_1_20_1","unstructured":"Willis R. A.1958.The borderland of embryology and pathology London p.148."}],"container-title":["The Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpath.1711370406","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/path.1711370406","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T11:57:32Z","timestamp":1760961452000},"score":1,"resource":{"primary":{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/10.1002\/path.1711370406"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1982,8]]},"references-count":19,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1982,8]]}},"alternative-id":["10.1002\/path.1711370406"],"URL":"https:\/\/doi.org\/10.1002\/path.1711370406","archive":["Portico"],"relation":{},"ISSN":["0022-3417","1096-9896"],"issn-type":[{"type":"print","value":"0022-3417"},{"type":"electronic","value":"1096-9896"}],"subject":[],"published":{"date-parts":[[1982,8]]},"assertion":[{"value":"1981-06-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2005-06-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}