{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T20:06:32Z","timestamp":1772049992880,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,6,15]],"date-time":"2005-06-15T00:00:00Z","timestamp":1118793600000},"content-version":"vor","delay-in-days":8081,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[1983,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Studies have been undertaken to search for humoral factors present in the plasma from animals undergoing inflammation which may promote specific cell types to adhere to vascular endothelium. We have tested both plasma from animals with \u201cacute\u201d pleural inflammation and animals with \u201cchronic\u201d carrageenan air pouch granulomata for the presence of leucocyte pro\u2010adhesive activity. Plasma from animals with carrageenan pleurisy had augmented polymorph adhesive activity. This activity was absent in the plasma from animals with air pouch granulomata. No such pro\u2010adhesive activity for mononuclear cells was detected in this plasma. We conclude that the initial influx of polymorphs during the early stages of inflammation may in part be due to systemic pro\u2010adhesive factors. It is proposed that these factors in combination with chemotaxins released at the lesion site are responsible for the early dominance of polymorphs.<\/jats:p>","DOI":"10.1002\/path.1711400103","type":"journal-article","created":{"date-parts":[[2005,6,21]],"date-time":"2005-06-21T14:48:21Z","timestamp":1119365301000},"page":"9-16","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The role of plasma factors in the adherence of leucocytes to vascular endothelial cells"],"prefix":"10.1002","volume":"140","author":[{"given":"A. D.","family":"Sedgwick","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. R.","family":"Mackay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. B.","family":"Bates","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. A.","family":"Willoughby","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,15]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1972.sp009808"},{"key":"e_1_2_1_3_1","volume-title":"Internat. Acad. Path. Monograph","author":"Cotran R.","year":"1982"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(78)90127-7"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1700910234"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI108354"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/139.1.69"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.38.1.225"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02004709"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00910715"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1953.63690130001006"},{"key":"e_1_2_1_12_1","first-page":"1","article-title":"The granulomatous inflammatory exudate","volume":"81","author":"Spector W. G.","year":"1969","journal-title":"Int. Rev. Exp. Path."},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00914188"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711110302"},{"key":"e_1_2_1_15_1","volume-title":"Chemotaxis and inflammation","author":"Wilkinson","year":"1974"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02027156"}],"container-title":["The Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpath.1711400103","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/path.1711400103","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T14:09:13Z","timestamp":1760969353000},"score":1,"resource":{"primary":{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/10.1002\/path.1711400103"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,5]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1983,5]]}},"alternative-id":["10.1002\/path.1711400103"],"URL":"https:\/\/doi.org\/10.1002\/path.1711400103","archive":["Portico"],"relation":{},"ISSN":["0022-3417","1096-9896"],"issn-type":[{"value":"0022-3417","type":"print"},{"value":"1096-9896","type":"electronic"}],"subject":[],"published":{"date-parts":[[1983,5]]},"assertion":[{"value":"1982-05-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2005-06-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}