{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T16:26:07Z","timestamp":1790267167585,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,6,16]],"date-time":"2005-06-16T00:00:00Z","timestamp":1118880000000},"content-version":"vor","delay-in-days":7929,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[1983,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A simple and reproducible model of acute haematogenous staphylococcal osteomyelitis is described. Twenty\u2010nine day\u2010old chickens were inoculated intravenously with 10<jats:sup>4<\/jats:sup>\u201310<jats:sup>8<\/jats:sup> viable organisms <jats:italic>Staphylococcus aureus<\/jats:italic> per kg body weight and were killed 1\u20138 days after inoculation. Macroscopic septic foci could be detected within 24 hr of inoculation and were most commonly situated in the metaphyseal region of the proximal tibia and distal femur. Lesions in other organs were not observed. The production of osteomyelitis was dependent on the bacterial inoculum size. It was estimated that 5.5 \u00d7 10<jats:sup>5<\/jats:sup> viable organisms per kg body weight of chicken were required to produce osteomyelitis in 50 per cent of injected chickens. Chicken weights were monitored throughout the experiment. A close negative correlation existed between the logarithm of the bacterial inoculum size and the chicken growth rate in the first 24 hr following inoculation (<jats:italic>r<\/jats:italic> = \u22120.968, <jats:italic>P<\/jats:italic>&lt; 0.01). The chicken growth rate was therefore used as an accurate predictor of osteomyelitis in individual chickens.<\/jats:p>","DOI":"10.1002\/path.1711410206","type":"journal-article","created":{"date-parts":[[2005,6,21]],"date-time":"2005-06-21T14:51:37Z","timestamp":1119365497000},"page":"157-167","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Acute haematogenous osteomyelitis: An experimental model"],"prefix":"10.1002","volume":"141","author":[{"given":"Kerry R.","family":"Emslie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. R.","family":"Ozanne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. M. L.","family":"Nade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,6,16]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"33","article-title":"Chronic staphylococcal osteomyelitis in rats","volume":"47","author":"Andriole V. T.","year":"1974","journal-title":"Yale J. Biol Med."},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.52B1.77"},{"key":"e_1_2_1_4_1","first-page":"1200","article-title":"Place of surgery in treatment of acute haematogenous osteomyelitis","volume":"64","author":"Jones G. Blundell","year":"1971","journal-title":"Proc. R. Soc. Med."},{"key":"e_1_2_1_5_1","first-page":"105","article-title":"Clinical problems in epiphyseal plate growth and development","volume":"23","author":"Brighton C. 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