{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:30:52Z","timestamp":1760956252605,"version":"build-2065373602"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,6,15]],"date-time":"2005-06-15T00:00:00Z","timestamp":1118793600000},"content-version":"vor","delay-in-days":7776,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[1984,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Administration of hexachloro\u20101:3\u2010butadiene (HCBD) intraperitoneally at a dose of 50 mg\/kg body weight caused necrosis of the proximal tubule of the mouse kidney. The earliest morphological changes detectable by light microscopy were observed after 4 h, and by 16 h extensive proximal tubular necrosis was seen throughout the cortex. Active tubular regeneration was apparent by day 5 and by day 14 substantial recovery of morphology had occurred. In the electron microscope mitochondrial swelling was seen 1 and 2 h after dosing in the S<jats:sub>1<\/jats:sub> and S<jats:sub>2<\/jats:sub> segments of the proximal tubule, whereas by 4 and 8 h the major pathological changes were confined to the lower S<jats:sub>2<\/jats:sub> and S<jats:sub>3<\/jats:sub> segments and consisted of mitochondrial swelling and cellular necrosis. The extent of renal injury and regeneration correlated well with measurement of renal function. In conclusion, HCBD produces necrosis of the S<jats:sub>2<\/jats:sub> and S<jats:sub>3<\/jats:sub> segments of the proximal tubule in the mouse, this pattern of injury is different from that seen in the rat where HCBD produces selective necrosis of the S<jats:sub>3<\/jats:sub> segment.<\/jats:p>","DOI":"10.1002\/path.1711420307","type":"journal-article","created":{"date-parts":[[2005,6,21]],"date-time":"2005-06-21T14:04:08Z","timestamp":1119362648000},"page":"195-203","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Hexachloro\u20101:3\u2010butadiene\u2010induced renal tubular necrosis in the mouse"],"prefix":"10.1002","volume":"142","author":[{"given":"J.","family":"Ishmael","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iona","family":"Pratt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. 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