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Dual heavy chain expression was common in many B\u2010cell malignant lymphomas and in the B\u2010cell lymphomas as a whole there was a predominance of lambda light chains. The expression of lambda light chain was associated with a poorer response to treatment and there was a tendency for such tumours to fall into the high grade lymphoma category. Surface membrane heavy chain expression, as assessed by staining intensity, was greatest in the lymphomas composed mostly of centrocytes and IgD expression was reduced in high grade lymphomas. The ratio of helper to suppressor T\u2010cells was reduced in centroblastic and immunoblastic lymphomas. 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