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Previous studies have documented argentaffin and argyrophil\u2010positive cells as well as gastrin\u2010like immunoreactivity in oesopha\u2010geal tissue extracts from patients with Barrett's mucosa. In the present study, 125 oesophageal biopsies obtained under direct vision at endoscopy from 22 patients with Barrett's oesophagus were systematically studied using fluorescence and peroxidase antiperoxidase single and double\u2010staining immunocytochemical methods employing highly specific antibodies to localize the following peptide\u2010containing cell types in Barrett's mucosa: gastrin, somatostatin, gastric inhibitory polypeptide, motilin, neurotensin and pancreatic glucagon. In addition, EC cells were localized using a cytochemical silver staining method. The results of this study indicate that EC cells and gastrin\u2010 and somatostatin\u2010containing endocrine cells are detectable in Barrett's epithelium.<\/jats:p>","DOI":"10.1002\/path.1711460310","type":"journal-article","created":{"date-parts":[[2005,6,22]],"date-time":"2005-06-22T10:32:02Z","timestamp":1119436322000},"page":"227-234","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Regulatory peptides in Barrett's oesophagus"],"prefix":"10.1002","volume":"146","author":[{"given":"Alison M. J.","family":"Buchan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan","family":"Grant","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. 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