{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T03:40:01Z","timestamp":1761104401027,"version":"build-2065373602"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,6,15]],"date-time":"2005-06-15T00:00:00Z","timestamp":1118793600000},"content-version":"vor","delay-in-days":7258,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[1985,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Subglottic stenosis is the most common serious complication of endotracheal intubation in the neonate with an incidence of between 1\u20138 per cent. While considered a complication of traumatic injury to the larynx and possibly associated with prolonged intubation, the pathogenesis is poorly understood and the pathology has not been described in detail. The nature of intubation induced injury has been investigated by examining step\u2010sections of 43 larynges removed from neonates post\u2010mortem who had been intubated for periods ranging from 10 min to 12 weeks. Focal ulceration was identified in the supraglottis and the anterior glottis. Similar injury was seen in the posterior glottis and subglottis but with more prolonged intubation there was full thickness mucosal necrosis, perichondritis and partial destruction of the arytenoid and cricoid cartilages. Although the severity of the injury progressed with time and many of the most severe injuries occurred early, in the second and third weeks of intubation, the larynx usually healed despite the continued presence of the endotracheal tube. Prolonged intubation on its own does not appear to be an important factor in the production of severe laryngeal injury nor, therefore, the subsequent complications such as subglottic stenosis.<\/jats:p>","DOI":"10.1002\/path.1711460403","type":"journal-article","created":{"date-parts":[[2005,6,22]],"date-time":"2005-06-22T10:33:19Z","timestamp":1119436399000},"page":"301-311","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The histopathology of the larynx in the neonate following endotracheal intubation"],"prefix":"10.1002","volume":"146","author":[{"given":"Stephen J. Susan","family":"Gould Howard","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,15]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348946607500407"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1977.00780230051006"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348948008900605"},{"key":"e_1_2_1_5_2","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1288\/00005537-197701000-00010","article-title":"Orotracheal intubation in the newborn","volume":"87","author":"Connor GH","year":"1977","journal-title":"Laryngoscope"},{"key":"e_1_2_1_6_2","first-page":"40","article-title":"Acquired subglottic stenosis in the very\u2010low\u2010birth\u2010weight infant","volume":"137","author":"Ratner I","year":"1983","journal-title":"Am J Dis Child"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1159\/000275081"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(75)80160-0"},{"key":"e_1_2_1_9_2","doi-asserted-by":"crossref","unstructured":"LindholmCE. Prolonged endotracheal intubation.Acta Anaesthesiol Scand1969; Suppl 33:1\u2013131.","DOI":"10.1111\/j.1399-6576.1969.tb00750.x"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.26.5.493"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-197802000-00001"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/40.5.347"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.3109\/00016487309139756"},{"key":"e_1_2_1_14_2","first-page":"253","volume-title":"Neonatal Intensive Care","author":"Choffat JM","year":"1976"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348947608500505"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1972.02110170024003"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.50.4.632"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.3109\/00016486209127370"},{"key":"e_1_2_1_19_2","unstructured":"BergstromJ. Laryngologic aspects of the treatment of acute barbiturate poisoning.Acta Otolaryngol Suppl.1962;173."},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1969.03150170029005"},{"key":"e_1_2_1_21_2","first-page":"511","article-title":"Histopathology of endotracheal intubation. An autopsy study of 99 cases","volume":"88","author":"Donnelly WH","year":"1969","journal-title":"Arch Pathol"},{"key":"e_1_2_1_22_2","first-page":"458","article-title":"Lesions dues a l'intubation endotracheale des nouveau\u2010nes","volume":"24","author":"Bozic C","year":"1969","journal-title":"Helv Paediat Acta"},{"key":"e_1_2_1_23_2","first-page":"392","article-title":"High tracheostomy and other errors, the chief causes of chronic laryngeal stenosis","volume":"32","author":"Jackson C","year":"1921","journal-title":"Surg Gynecol Obstet"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348947708600620"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198207000-00018"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1982.00790590049014"}],"container-title":["The Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpath.1711460403","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/path.1711460403","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T13:50:36Z","timestamp":1761054636000},"score":1,"resource":{"primary":{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/10.1002\/path.1711460403"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,8]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1985,8]]}},"alternative-id":["10.1002\/path.1711460403"],"URL":"https:\/\/doi.org\/10.1002\/path.1711460403","archive":["Portico"],"relation":{},"ISSN":["0022-3417","1096-9896"],"issn-type":[{"type":"print","value":"0022-3417"},{"type":"electronic","value":"1096-9896"}],"subject":[],"published":{"date-parts":[[1985,8]]},"assertion":[{"value":"1984-11-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1984-12-31","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2005-06-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}