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Bilaterality and multifocality were features in cancerous and benign breasts and a similar range of scar histological appearance was apparent in both types. The histological features of 103 radial scars were tabulated to compare the association of characteristics within individual scars, and the information used to formulate modes of development and progression. The \u2018early\u2019 stage appeared to correlate with central chronic inflammatory response, many spindle cells and minor fibroelastotic distortion of parenchyma; the \u2018late\u2019 stage showed few spindle cells and dominant fibroclastosis with considerable distortion and separation of parenchymal elements. No support was found for the concept that the lesion is premalignant. Rather it belongs to the spectrum of sclerosing alterations affecting the breast parenchyma which ranges from physiological through to clearly pathological changes. Position in the spectrum depends upon the extent and degree of change.<\/jats:p>","DOI":"10.1002\/path.1711470104","type":"journal-article","created":{"date-parts":[[2005,6,22]],"date-time":"2005-06-22T10:34:20Z","timestamp":1119436460000},"page":"23-32","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["Radial scars of benign and malignant breasts: Comparative features and significance"],"prefix":"10.1002","volume":"147","author":[{"given":"T. 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