{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T00:29:26Z","timestamp":1761092966234,"version":"build-2065373602"},"reference-count":7,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,6,15]],"date-time":"2005-06-15T00:00:00Z","timestamp":1118793600000},"content-version":"vor","delay-in-days":7015,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[1986,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Tumours were raised in both congenitally athymie (\u2018nude\u2019) Swiss mice and in neonatally thymcctomized, Ara\u2010C\u2010 protectcd, whole\u2010body irradiated CBA mice by subcutaneous inoculation of cells from a variety of cultured human lines. In both types of animal, tumours tended to grow massively at the site of inoculation, with some infiltration of adjacent tissues hut only rarely with evidence of metastatic spread. Tumours derived from Burkitt's lymphoma (BL) lines or from EB virus\u2010transformed lymphoblastoid cell lines (LCL) were nil classified as high grade malignant lymphomas with a limited range of appearances on conventional histological examination. In the material studied there were no consistent features distinguishing BL\u2010derived from LCL\u2010dcrivcd tumours. Cell lines originating from other haematopoietic malignancics tended to produced tumours interpreted us immunoblastic lymphomas though there were distinctive characteristics in some cases, such as highly convoluted or pleomorphic nuclei in the cells of some tumours derived Prom T\u2010cell leukaemia lines and plasmacytoid differentiation in tumours originating from myeloma lines. Malignant cell lines of epithelial origin gave rise to tumours wilh the histological appearances of anaplastic carcinomas readily distinguishable from the high grade lymphomas produced by haematopoietic cells.<\/jats:p>","DOI":"10.1002\/path.1711480405","type":"journal-article","created":{"date-parts":[[2005,6,22]],"date-time":"2005-06-22T10:39:19Z","timestamp":1119436759000},"page":"293-300","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["The gross pathology and histological features of tumours produced by inoculation of human cell lines into immune\u2010deprived mice"],"prefix":"10.1002","volume":"148","author":[{"given":"A.","family":"Busuttil","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. T.","family":"O'Conor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. E.","family":"Foster","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Gurtsevitch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. E. N.","family":"Morten","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. M.","family":"Steel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,15]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"7","volume-title":"The Transformed Cell","author":"Skehan P","year":"1981"},{"volume-title":"The Nude Mouse in Experimental and Clinical Research","year":"1975","author":"Fogh J","key":"e_1_2_1_3_2"},{"doi-asserted-by":"publisher","key":"e_1_2_1_4_2","DOI":"10.1038\/bjc.1978.30"},{"doi-asserted-by":"publisher","key":"e_1_2_1_5_2","DOI":"10.1002\/ijc.2910340406"},{"doi-asserted-by":"publisher","key":"e_1_2_1_6_2","DOI":"10.1258\/002367785780942561"},{"volume-title":"The Nude Mouse as a Diagnostic Tool iti Hunam Tumor Cell Research","year":"1978","author":"Fogh J","key":"e_1_2_1_7_2"},{"volume-title":"Theory and Practice of Histological Techniques","year":"1982","author":"Bancroft JD","key":"e_1_2_1_8_2"}],"container-title":["The Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpath.1711480405","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/path.1711480405","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T10:00:47Z","timestamp":1761040847000},"score":1,"resource":{"primary":{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/10.1002\/path.1711480405"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,4]]},"references-count":7,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1986,4]]}},"alternative-id":["10.1002\/path.1711480405"],"URL":"https:\/\/doi.org\/10.1002\/path.1711480405","archive":["Portico"],"relation":{},"ISSN":["0022-3417","1096-9896"],"issn-type":[{"type":"print","value":"0022-3417"},{"type":"electronic","value":"1096-9896"}],"subject":[],"published":{"date-parts":[[1986,4]]},"assertion":[{"value":"1981-10-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1985-11-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2005-06-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}