{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T19:42:37Z","timestamp":1761162157692,"version":"build-2065373602"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,6,15]],"date-time":"2005-06-15T00:00:00Z","timestamp":1118793600000},"content-version":"vor","delay-in-days":6862,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[1986,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Six examples of histologically diagnosed, non\u2010invasive breast carcinomas were studied by electron microscopy to elucidate the ultrastructural features for an accurate diagnosis of\n                    <jats:italic>in situ<\/jats:italic>\n                    carcinoma. The results obtained revealed two patterns of basal lamina\/stromal cells relationship. One pattern showed intact basal lamina with associated periductal stromal cells consisting entirely of fibroblasts, the other pattern showed disruption of basal lamina by gaps and malignant cell protrusions with associated stromal cells consisting of both fibroblasts and myofibroblasts. As myofibroblasts are not a component of normal breast stroma but are known to be a prominent feature in the stroma of infiltrating breast carcinoma, the present observations suggest that myofibroblastic proliferation around\n                    <jats:italic>in situ<\/jats:italic>\n                    carcinoma represents an early sign of carcinomatous infiltration. Hence the definitive diagnosis of non\u2010invasive carcinoma of the breast requires an intact basal lamina and a complete absence of a myofibroblastic reaction.\n                  <\/jats:p>","DOI":"10.1002\/path.1711500108","type":"journal-article","created":{"date-parts":[[2005,6,22]],"date-time":"2005-06-22T10:43:33Z","timestamp":1119437013000},"page":"43-49","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Stromal changes in early invasive and non\u2010invasive breast carcinoma: An ultrastructural study"],"prefix":"10.1002","volume":"150","author":[{"given":"Salah O.","family":"Tamimi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,15]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"266","volume-title":"Major Problems in Pathology","author":"Azzopardi JN","year":"1979"},{"key":"e_1_2_1_3_2","first-page":"887","article-title":"The behaviour of basement membranes in intraductal carcinoma of the breast","volume":"35","author":"Ozzello L","year":"1959","journal-title":"Am J Pathol"},{"key":"e_1_2_1_4_2","first-page":"381","volume-title":"Human and Experimental Breast Cancer","author":"Bonser GM","year":"1961"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197012)26:6<1186::AID-CNCR2820260603>3.0.CO;2-C"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02110120"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(196904)23:4<822::AID-CNCR2820230416>3.0.CO;2-3"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711100103"},{"key":"e_1_2_1_9_2","first-page":"409","volume-title":"Electron Microscopy in Human Medicine","author":"Ozzello L","year":"1979"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.173.3996.548"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02147594"},{"key":"e_1_2_1_12_2","first-page":"131","article-title":"Dupuytren's contracture: fibroblast contraction? 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An ultrastructural comparison with certain duct carcinomas and benign lesions","volume":"125","author":"Carter D","year":"1969","journal-title":"Johns Hopkins Med J"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(196912)24:6<1152::AID-CNCR2820240614>3.0.CO;2-5"},{"key":"e_1_2_1_23_2","first-page":"1","volume-title":"Atlas of Ultrastructure of Human Breast Diseases","author":"Ahmed A","year":"1978"},{"key":"e_1_2_1_24_2","first-page":"314","article-title":"Basal lamina scaffold\u2010anatomy and significance for maintenance of orderly tissue structure","volume":"77","author":"Vracko R","year":"1974","journal-title":"Am J Pathol"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-197912000-00006"},{"key":"e_1_2_1_26_2","first-page":"181","volume-title":"Major Problems in Pathology","author":"Azzopardi JN","year":"1979"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711470105"},{"key":"e_1_2_1_28_2","unstructured":"TamimiSO AhmedA.Stromal changes in invasive breast carcinoma: An ultrastructural study. 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