{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T02:39:59Z","timestamp":1761100799279,"version":"build-2065373602"},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,6,15]],"date-time":"2005-06-15T00:00:00Z","timestamp":1118793600000},"content-version":"vor","delay-in-days":6832,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[1986,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The monoclonal antibodies MB1 and MT1, which detect B cells and T cells respectively, have been applied to human lymphoid tissues. The distribution of staining within paraffin sections was compared with that observed using frozen sections and was found to be identical. The antibodies were then applied to paraffin sections of 19 B\u2010cell lymphomas and 10 T\u2010cell lesions in which full immunophenotyping had been performed. The B lymphomas all consisted of a large majority of MB1 positive cells with a variable infiltrate of small MT1 positive lymphocytes. The T cell lesions consisted of MT1 positive cells with few MB1 positive cells except in residual B cell areas of lymph nodes. In paraffin sections from cases of Hodgkin's disease anti\u2010Leu M1 identified Reed\u2010Sternberg cells and their variants and MB1 and MT1 showed a similar distribution of B cells and T cells to that demonstrated in previous studies using frozen sections. The results show that MB1 and MT1 are useful markers for B and T cells in routinely fixed paraffin embedded tissue. In conjunction with anti\u2010Leu M1 they provide a valuable panel of antisera for the examination of lymph nodes and other biopsies when frozen tissue is not available.<\/jats:p>","DOI":"10.1002\/path.1711500203","type":"journal-article","created":{"date-parts":[[2005,6,22]],"date-time":"2005-06-22T10:43:10Z","timestamp":1119436990000},"page":"89-101","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":83,"title":["The demonstration of B\u2010cell, T\u2010cell and myeloid antigens in paraffin sections"],"prefix":"10.1002","volume":"150","author":[{"given":"K. P.","family":"West","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Warford","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Fray","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Allen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. C.","family":"Campbell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Lauder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,15]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/82.1.29"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19850215)55:4<728::AID-CNCR2820550409>3.0.CO;2-S"},{"key":"e_1_2_1_4_2","first-page":"209","article-title":"Phenotypic expression of Hodgkin's and Reed\u2010Sternberg cells in Hodgkin's disease","volume":"118","author":"Hsu S","year":"1985","journal-title":"Am J Pathol"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0019-2791(69)90177-3"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.31.5.454"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01920206"},{"volume-title":"Leucocyte Typing\u2010Human Leucocyte Differentiation Antigens Detected by Monoclonal Antibodies","year":"1984","author":"Bernard A","key":"e_1_2_1_8_2"},{"key":"e_1_2_1_9_2","unstructured":"2nd International Workshop on Leucocyte Differentiation Antigens.Boston 1984."},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.153.4.753"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1177\/28.8.7003001"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.39.4.399"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1983.52"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1983.tb02299.x"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.38.11.1241"},{"key":"e_1_2_1_16_2","first-page":"199","article-title":"L and H variants of Reed\u2010Sternberg cells express sialylated Leu M1 antigen","volume":"122","author":"Hsu SM","year":"1986","journal-title":"Am JPathol"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1984.74"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19850215)55:4<683::AID-CNCR2820550402>3.0.CO;2-O"}],"container-title":["The Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpath.1711500203","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/path.1711500203","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T14:40:32Z","timestamp":1761057632000},"score":1,"resource":{"primary":{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/10.1002\/path.1711500203"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,10]]},"references-count":17,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1986,10]]}},"alternative-id":["10.1002\/path.1711500203"],"URL":"https:\/\/doi.org\/10.1002\/path.1711500203","archive":["Portico"],"relation":{},"ISSN":["0022-3417","1096-9896"],"issn-type":[{"type":"print","value":"0022-3417"},{"type":"electronic","value":"1096-9896"}],"subject":[],"published":{"date-parts":[[1986,10]]},"assertion":[{"value":"1986-04-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1986-05-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2005-06-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}