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Both compounds induce renal papillary necrosis but paracetamol produces accumulation of non\u2010cellular material in the interstitial space, less damage to interstitial cells, more damage to tubular epithelium, and more severe necrosis of proximal convoluted tubules. In both cortex and papilla only a small fraction of the cells at risk are affected. It is concluded that the findings are consistent with a synergistic nephrotoxic effect between the two compounds, but that the lesions are not sufficiently severe for the natural history of analgesic nephropathy to be wholly explicable by such synergism.<\/jats:p>","DOI":"10.1002\/path.1711510103","type":"journal-article","created":{"date-parts":[[2005,6,22]],"date-time":"2005-06-22T10:47:15Z","timestamp":1119437235000},"page":"11-19","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Lesions of the renal papilla induced by paracetamol"],"prefix":"10.1002","volume":"151","author":[{"given":"M. A.","family":"Henry","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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