{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T02:39:52Z","timestamp":1761100792018,"version":"build-2065373602"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,6,15]],"date-time":"2005-06-15T00:00:00Z","timestamp":1118793600000},"content-version":"vor","delay-in-days":6620,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[1987,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Primary gastric lymphoma, (PGL), is thought to be a tumour of follicle centre cell origin containing centrocyte\u2010like (CCL) cells, and plasma cell components. The advent of novel leucocyte antibodies reactive in paraffin sections and improved techniques for the demonstration of immunoglobulin (Ig) in tissues has permitted a reassessment of the histogenesis of PGL. Our results have shown that PGL is a tumour of CCL cells with plasma cell differentiation in a minority of cases. Follicles were reactive, as defined by polytypic expression of Ig, in each case but selective invasion of reactive follicles by neoplastic CCL cells often led to a misleading appearance of malignancy. CCL cells bear close similarities to marginal zone cells which have been defined as a distinct non\u2010circulating <jats:bold>B<\/jats:bold>\u2010cell lineage. This could account for the favourable clinical behaviour of PGL.<\/jats:p>","DOI":"10.1002\/path.1711520102","type":"journal-article","created":{"date-parts":[[2005,6,22]],"date-time":"2005-06-22T10:50:04Z","timestamp":1119437404000},"page":"1-11","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":88,"title":["Primary B\u2010cell gastric lymphoma\u2014a reassessment of its histogenesis"],"prefix":"10.1002","volume":"152","author":[{"given":"Michael J.","family":"Myhre","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter G.","family":"Isaacson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,15]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(86)80157-5"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711510304"},{"key":"e_1_2_1_4_2","doi-asserted-by":"crossref","unstructured":"NortonA IsaacsonPG.Detailed phenotypic analysis of B\u2010cell lymphoma using a panel of antibodies reactive in routinely fixed wax embedded tissue.Am J Pathol1987; in press.","DOI":"10.1002\/path.1711510304"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19831015)52:8<1410::AID-CNCR2820520813>3.0.CO;2-3"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19840601)53:11<2515::AID-CNCR2820531125>3.0.CO;2-C"},{"key":"e_1_2_1_7_2","first-page":"123","article-title":"Demonstration of B\u2010cell, T\u2010cell, and myeloid antigens in paraffin sections from malignant lymphomas","volume":"148","author":"West KP","year":"1986","journal-title":"J Pathol"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.133.2.1028"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00708326"},{"key":"e_1_2_1_10_2","first-page":"63","article-title":"Functional subsets of human helper\u2010inducer cells defined by a new monoclonal antibody, UCHL1","volume":"58","author":"Smith SH","year":"1986","journal-title":"Immunology"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830140307"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1177\/27.8.90074"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1984.tb02377.x"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19811201)48:11<2518::AID-CNCR2820481129>3.0.CO;2-4"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00443482"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1985.tb02972.x"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.26.7.672"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.27.4.405"},{"key":"e_1_2_1_19_2","first-page":"607","article-title":"The human gut contains a novel population of B lymphocytes which resemble marginal zone cells","volume":"62","author":"Spencer J","year":"1985","journal-title":"Clin exp Immunol"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830111103"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(82)90032-9"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/86.4.475"},{"key":"e_1_2_1_23_2","first-page":"266","article-title":"Immature sinus histiocytosis. 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