{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T08:59:54Z","timestamp":1762160394712,"version":"build-2065373602"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,6,15]],"date-time":"2005-06-15T00:00:00Z","timestamp":1118793600000},"content-version":"vor","delay-in-days":6589,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[1987,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A sensitive <jats:italic>in situ<\/jats:italic> hybridization technique for the demonstration of human papillomavirus (HPV) employing a biotin\u2010streptavidin polyalkaline phosphatase complex has been successfully applied to formalin\u2010fixed, paraffin processed tissue obtained from a selected series of patients with ano\u2010genital lesions. Benign condylomata from males and females showed the presence of HPV 6 and 11. Two cases of vulval intraepithelial neoplasia showed HPV 16. Four cases of squamous carcinoma of the anal canal also showed HPV 16 in the tumour or in the adjacent pre\u2010invasive neoplastic epithelium. A case of malignant transformation in a cervical condyloma was associated with HPV 6 and 11. This technique permits the retrospective evaluation of routinely processed material thus widening the investigative spectrum for HPV.<\/jats:p>","DOI":"10.1002\/path.1711520203","type":"journal-article","created":{"date-parts":[[2005,6,22]],"date-time":"2005-06-22T10:51:09Z","timestamp":1119437469000},"page":"77-82","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Demonstration of human papilloma virus types in paraffin processed tissue from human anogenital lesions by <i>in<\/i>\u2010<i>situ<\/i> DNA hybridisation"],"prefix":"10.1002","volume":"152","author":[{"given":"Michael","family":"Wells","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharon","family":"Griffiths","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fraser","family":"Lewis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Colin C.","family":"Bird","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,15]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"31","article-title":"The biology of papillomavirus and their role in oncogenesis","volume":"5","author":"Smith KT","year":"1985","journal-title":"Anticancer Res"},{"key":"e_1_2_1_3_2","first-page":"15","article-title":"Genital papillomavirus infections","volume":"32","author":"Zur Hausen H","year":"1985","journal-title":"Prog Med Virol"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711450302"},{"key":"e_1_2_1_5_2","first-page":"104","article-title":"Human papillomavirus","volume":"34","author":"Singer A","year":"1985","journal-title":"Br J Hosp Med"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.34.5.524"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.34.5.532"},{"key":"e_1_2_1_8_2","first-page":"476","article-title":"Noncondylomatous cervical wart virus infection","volume":"55","author":"Reid R","year":"1980","journal-title":"Obstet Gynecol."},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198110000-00008"},{"key":"e_1_2_1_10_2","first-page":"727","article-title":"Immunologic identification of papillomavirus antigen in condyloma tissues from the female genital tract","volume":"56","author":"Woodruff JD","year":"1980","journal-title":"Obstet Gynecol"},{"key":"e_1_2_1_11_2","first-page":"831","article-title":"Confirmation of the papillomavirus etiology of condylomatous cervix lesions by the peroxidaseantiperoxidase technique","volume":"66","author":"Morin C","year":"1981","journal-title":"JNCI"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(81)90087-9"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/300771a0"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.293.6539.93"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004347-198509000-00005"},{"key":"e_1_2_1_16_2","first-page":"174","article-title":"In situ hybridisation analysis of HPV 16 DNA sequences in early cervical neoplasia","volume":"123","author":"Crum CP","year":"1986","journal-title":"Am J Pathol"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.40.2.163"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.1890160307"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1177\/34.1.3001177"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)92067-2"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006250-198603001-00021"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004347-198512000-00010"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1985.tb01362.x"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)90168-6"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-66-7-1515"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910380509"},{"key":"e_1_2_1_27_2","unstructured":"MacNabJ. 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