{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T00:41:26Z","timestamp":1761093686572,"version":"build-2065373602"},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,6,16]],"date-time":"2005-06-16T00:00:00Z","timestamp":1118880000000},"content-version":"vor","delay-in-days":6437,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[1987,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Leu\u2010M1 is a differentiation antigen present in human myelomonocytic cells. Seventy\u2010seven acute leukaemias were retrospectively stained with anti\u2010Leu\u2010M1 using the immunoperoxidase technique on Bouin\u2010fixed paraffin\u2010embedded sections. The subjects were 44 acute lymphoblastic leukaemias (ALL) and 33 acute myeloid leukaemias (AML) previously characterized by cytochemical and immunologic (cell suspension) methods. Leu\u2010M1 was positive in all the AML and in half of the ALL cases. These results suggest that Leu\u2010M1 does not allow differentiation between AML and ALL. For the ALL cases Leu\u2010M1 was positive in 15\/28 B\u2010cell types, 4\/12 T\u2010cell type and 3\/4 \u2018null\u2019\u2010cell type cases. Thus, this antibody is of no assistance in defining types B, T, or \u2018null\u2019 in ALL. Leu\u2010M1 was also studied on paraffin sections of 34 high grade malignant lymphomas. The antibody was negative in all 13 B\u2010cell lymphomas (lymphoblastic: 6; immunoblastic: 7) and in all 4 \u2018null\u2019 cell lymphomas. It was positive in 4\/9 peripheral T\u2010cell type, the other T\u2010cell lymphomas (lymphoblastic: 5; immunoblastic:3) remaining negative. Thus, Leu\u2010M1 may be positive in T\u2010cell lymphomas but it is negative in B\u2010cell lymphomas and is always negative in B or T lymphoblastic types. It seems that lymphoblasts are Leu\u2010M1 negative in non\u2010Hodgkin's lymphoma and may be Leu\u2010M1 positive in leukaemias.<\/jats:p>","DOI":"10.1002\/path.1711530306","type":"journal-article","created":{"date-parts":[[2005,6,22]],"date-time":"2005-06-22T13:19:17Z","timestamp":1119446357000},"page":"225-232","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Leu\u2010M1 antigen expression in acute leukaemias"],"prefix":"10.1002","volume":"153","author":[{"given":"Antoine","family":"De Mascarel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean Michel","family":"Coindre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabelle","family":"De 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