{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T16:46:16Z","timestamp":1772469976601,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,6,16]],"date-time":"2005-06-16T00:00:00Z","timestamp":1118880000000},"content-version":"vor","delay-in-days":6255,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[1988,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The expression of low molecular weight cytokeratins (normally expressed only in simple epithelia) in intraepithelial neoplasia of grade CIN III or greater in cervical biopsies has recently been described by Bobrow\n                    <jats:italic>et al.<\/jats:italic>\n                    Our study of 127 cases confirms this finding and in addition we compare the use of three monoclonal antibodies, namely NCL\u20105D3, CAM 5.2, and PKK1, in demonstrating the phenomenon. Both NCL\u20105D3 and CAM 5.2 give consistently negative results for non\u2010neoplastic stratified squamous epithelium, as well as CIN I and CIN II lesions, whilst staining about 30 per cent of CIN III biopsies and most carcinomas. PKK1, on the other hand, stained 50 per cent of non\u2010neoplastic epithelia and thus did not serve as a marker of severe dysplasia. The possible implications of these observations are discussed.\n                  <\/jats:p>","DOI":"10.1002\/path.1711550111","type":"journal-article","created":{"date-parts":[[2005,6,22]],"date-time":"2005-06-22T13:23:41Z","timestamp":1119446621000},"page":"71-75","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Cytokeratins in cervical dysplasia and neoplasia: A comparative study of immunohistochemical staining using monoclonai antibodies NCL\u20105D3, CAM 5\u00b72, and PKK1"],"prefix":"10.1002","volume":"155","author":[{"given":"Brian","family":"Angus","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sam","family":"Kiberu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Purvis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda","family":"Wilkinson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles H. W.","family":"Horne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,16]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(82)90400-7"},{"key":"e_1_2_1_3_2","first-page":"309","article-title":"Monoclonal antibodies to human intermediate filament proteins. II. Distribution of filament protein in normal human tissues","volume":"114","author":"Gown AM","year":"1984","journal-title":"Am J Pathol"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711480203"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711500112"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.37.9.975"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1986.tb02574.x"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711530411"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.35.1.1"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.36.6.616"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.34.5.532"},{"key":"e_1_2_1_12_2","first-page":"599","article-title":"Cytokeratins of normal epithelia and some neoplasms of the female genital tract","volume":"49","author":"Moll R","year":"1983","journal-title":"Lab Invest"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0344-0338(84)80058-8"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004347-198512000-00003"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.33.6.517"},{"key":"e_1_2_1_16_2","unstructured":"FerenczyA. Cervical intraepithelial neoplasia. In: Blaustein A ed.Pathology of the Female Genital Tract."},{"key":"e_1_2_1_17_2","first-page":"3252","article-title":"Histological types of carcinoma of uterine cervix and the detectability of human papillomavirus DNA","volume":"45","author":"Fukushima M","year":"1985","journal-title":"Cancer Res"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.3109\/00313028709065144"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1984.tb03684.x"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1983.tb06447.x"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.36.5.535"}],"container-title":["The Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpath.1711550111","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/path.1711550111","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T17:33:24Z","timestamp":1761068004000},"score":1,"resource":{"primary":{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/10.1002\/path.1711550111"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,5]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1988,5]]}},"alternative-id":["10.1002\/path.1711550111"],"URL":"https:\/\/doi.org\/10.1002\/path.1711550111","archive":["Portico"],"relation":{},"ISSN":["0022-3417","1096-9896"],"issn-type":[{"value":"0022-3417","type":"print"},{"value":"1096-9896","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,5]]},"assertion":[{"value":"1987-08-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1987-12-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2005-06-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}