{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T00:39:28Z","timestamp":1761093568809,"version":"build-2065373602"},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,6,16]],"date-time":"2005-06-16T00:00:00Z","timestamp":1118880000000},"content-version":"vor","delay-in-days":6194,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[1988,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In this prospective study, axillary clearance specimens from consecutive routine mastectomies and wide excisions for carcinoma were divided into three segments by sutures in the theatre: apical (furthest from the tumour), mid and basal (nearest to the tumour) segments. Each specimen was then randomized to either formalin or Carnoy's fixation. Following fixation, lymph nodes were dissected from each of the three segments, sectioned once through the hilum, and examined microscopically.<\/jats:p><jats:p>There was a significant (<jats:italic>P<\/jats:italic> &lt; 0\u00b705) difference in the total number and number of reactive lymph nodes harvested from Carnoy's compared with formalin\u2010fixed material. The number of nodes containing metastatic carcinoma was not significantly different (<jats:italic>P<\/jats:italic> = 0\u00b764).<\/jats:p><jats:p>In several cases, involved apical segment lymph nodes were found with no involvement of the proximal groups; this observation may have serious implications for the procedure of proximal lymph node sampling in the surgical management of breast cancer. It is suggested that clearing of axillary contents with Carnoy's fixative does not provide any additional information of clinical significance, although it may allow the pathologist to identify lymph nodes rapidly.<\/jats:p>","DOI":"10.1002\/path.1711550307","type":"journal-article","created":{"date-parts":[[2005,6,22]],"date-time":"2005-06-22T13:25:59Z","timestamp":1119446759000},"page":"221-224","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Axillary lymph node status in carcinoma of the breast"],"prefix":"10.1002","volume":"155","author":[{"given":"Vanessa","family":"Lewis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Rice","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,16]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-198111000-00005"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197404)33:4<1145::AID-CNCR2820330438>3.0.CO;2-0"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197601)37:1<111::AID-CNCR2820370117>3.0.CO;2-K"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197803)41:3<1170::AID-CNCR2820410355>3.0.CO;2-I"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-196809000-00004"},{"volume-title":"Diseases of the Breast","year":"1971","author":"Haagensen CD","key":"e_1_2_1_7_2"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197208)30:2<594::AID-CNCR2820300241>3.0.CO;2-2"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19831101)52:9<1551::AID-CNCR2820520902>3.0.CO;2-3"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-198004000-00006"},{"volume-title":"Theory and Practice of Histological Techniques","year":"1977","author":"Bancroft JD","key":"e_1_2_1_11_2"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1948.01240020486005"},{"key":"e_1_2_1_13_2","first-page":"604","article-title":"Distribution of axillary lymph node metastases in carcinoma of the breast","volume":"136","author":"Davis HH","year":"1952","journal-title":"Ann Surg"},{"first-page":"1009","volume-title":"Systemic Pathology","author":"Symmers WStC","key":"e_1_2_1_14_2"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19840315)53:6<1329::AID-CNCR2820530618>3.0.CO;2-U"},{"key":"e_1_2_1_16_2","first-page":"121","article-title":"Routine histological investigation of the axillary lymph nodes in breast cancer","volume":"8","author":"Hartveit F","year":"1982","journal-title":"Clin Oncol"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-198503000-00009"},{"volume-title":"Statistical Methods","year":"1967","author":"Snedecor GW","key":"e_1_2_1_18_2"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-198209000-00017"}],"container-title":["The Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpath.1711550307","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/path.1711550307","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T12:03:59Z","timestamp":1761048239000},"score":1,"resource":{"primary":{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/10.1002\/path.1711550307"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,7]]},"references-count":18,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1988,7]]}},"alternative-id":["10.1002\/path.1711550307"],"URL":"https:\/\/doi.org\/10.1002\/path.1711550307","archive":["Portico"],"relation":{},"ISSN":["0022-3417","1096-9896"],"issn-type":[{"type":"print","value":"0022-3417"},{"type":"electronic","value":"1096-9896"}],"subject":[],"published":{"date-parts":[[1988,7]]},"assertion":[{"value":"1987-11-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1988-01-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2005-06-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}