{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T13:10:53Z","timestamp":1777468253523,"version":"3.51.4"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,6,15]],"date-time":"2005-06-15T00:00:00Z","timestamp":1118793600000},"content-version":"vor","delay-in-days":6131,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[1988,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In this study, alcohol\u2010induced histological lesions in a short\u2010term experimental rat model were compared with those characteristic of human alcoholic liver disease. In the rat model used, pretreatment with carbon tetrachloride (CCl<jats:sub>4<\/jats:sub>) for 6 weeks was employed possibly to sensitize the liver for the effects of alcohol and shorten the time of induction of alcoholic liver disease. After 6 weeks of CCl<jats:sub>4<\/jats:sub> treatment, subsequent maintenance on drinking water containing up to 10 per cent alcohol for 7 weeks potentiated liver fibroplasia as compared with non\u2010alcohol\u2010treated rats. However, steatosis and alcoholic hepatitis, as histological evidence for alcoholic liver disease as seen in humans, were not observed. In non\u2010CCl<jats:sub>4<\/jats:sub>\u2010pretreated control animals, alcohol administration had no effect on liver histology.<\/jats:p><jats:p>It can be concluded that in the model used, CCl<jats:sub>4<\/jats:sub> pretreatment sensitizes the liver to increase collagen deposition following alcohol administration, but not to steatosis or alcoholic hepatitis as seen in human alcoholic liver disease. In this experimental set\u2010up, direct metabolic interaction of CCl<jats:sub>4<\/jats:sub> with alcohol as a cause of the increased fibroplasia can be excluded.<\/jats:p>","DOI":"10.1002\/path.1711560106","type":"journal-article","created":{"date-parts":[[2005,6,22]],"date-time":"2005-06-22T13:26:33Z","timestamp":1119446793000},"page":"15-21","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Synergism between ethanol and carbon tetrachloride in the generation of liver fibrosis"],"prefix":"10.1002","volume":"156","author":[{"given":"Anne","family":"Bosma","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriaan","family":"Brouwer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wilfried F.","family":"Seifert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dick L.","family":"Knook","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,15]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840030101"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840060503"},{"key":"e_1_2_1_4_2","first-page":"253","volume-title":"Progress in Liver Diseases","author":"Lieber CS","year":"1986"},{"key":"e_1_2_1_5_2","first-page":"85","volume-title":"Pharmacological, Morphological and Physiological Aspects of Liver Ageing","author":"Geerts A","year":"1984"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00491759"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(61)90291-0"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(67)90167-2"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.2307\/3576456"},{"key":"e_1_2_1_10_2","first-page":"78","volume-title":"Liver Biopsy Interpretation","author":"Scheuer PJ","year":"1980"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(81)91984-X"},{"key":"e_1_2_1_12_2","first-page":"116","volume-title":"The Liver Annual 5","author":"Lieber CS","year":"1986"},{"key":"e_1_2_1_13_2","first-page":"559","article-title":"Early perivenular sclerosis in alcoholic fatty liver injury","volume":"3","author":"Van Waes L","year":"1983","journal-title":"Gastroenterology"},{"key":"e_1_2_1_14_2","first-page":"695","article-title":"Histogenesis of alcoholic fibrosis and cirrhosis in the baboon","volume":"98","author":"Popper H","year":"1980","journal-title":"Am J Pathol"},{"key":"e_1_2_1_15_2","first-page":"145","article-title":"Ultrastructure of initial stages of perivenular fibrosis in alcohol\u2010fed baboons","volume":"106","author":"Nakano M","year":"1982","journal-title":"Am J Pathol"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840030414"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1985.03360050065027"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840030118"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01965096"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1986.tb05605.x"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.3109\/00498258309052214"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(74)80142-3"}],"container-title":["The Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpath.1711560106","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/path.1711560106","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T14:48:48Z","timestamp":1761058128000},"score":1,"resource":{"primary":{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/10.1002\/path.1711560106"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,9]]},"references-count":21,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1988,9]]}},"alternative-id":["10.1002\/path.1711560106"],"URL":"https:\/\/doi.org\/10.1002\/path.1711560106","archive":["Portico"],"relation":{},"ISSN":["0022-3417","1096-9896"],"issn-type":[{"value":"0022-3417","type":"print"},{"value":"1096-9896","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,9]]},"assertion":[{"value":"1987-11-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1988-02-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2005-06-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}