{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T02:39:28Z","timestamp":1761100768739,"version":"build-2065373602"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,6,15]],"date-time":"2005-06-15T00:00:00Z","timestamp":1118793600000},"content-version":"vor","delay-in-days":6131,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[1988,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The present work was carried out to look for the ultrastructural substrate of the contact zones between Langerhans cells and lymphocytes. A high resolution electron microscopic analysis of the contact zones between Langerhans cells and lymphocytes was performed. The material used for this study was obtained from experimental contact dermatitis in mice, and human cervical squamous carcinoma and mycosis fungoides. Three types of cell\u2014cell binding were found. Type I is a junction\u2010like structure characterized by the presence of intercellular bridges. It is suggested that this contact might represent a fixation mechanism between the two cells. Type II is characterized by a glycocalyx\u2014glycocalyx continuity. An immunological function\u2014recognition and antigen presentation\u2014is proposed for this type of contact. Type III is a septilaminar tight contact area which seems to be a gap junction.<\/jats:p><jats:p>It is suggested that all these types of physical contact might be the morphological expression of interaction between antigen presenting cells and lymphocytes.<\/jats:p>","DOI":"10.1002\/path.1711560108","type":"journal-article","created":{"date-parts":[[2005,6,22]],"date-time":"2005-06-22T13:26:33Z","timestamp":1119446793000},"page":"29-36","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Ultrastructural characteristics of the contact zones between langerhans cells and lymphocytes"],"prefix":"10.1002","volume":"156","author":[{"given":"Miguel","family":"Concha","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos D.","family":"Figueroa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Italo","family":"Caorsi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,15]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.121.5.2005"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0171-2985(84)80118-7"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12275562"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0008-8749(75)90071-4"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.1979.tb01159.x"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.3109\/01913128209016636"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.3109\/01913128409141851"},{"key":"e_1_2_1_9_2","first-page":"237","article-title":"Sur la pr\u00e9sence d'agr\u00e9gats constitu\u00e9s de cellules de Langerhans et cellular lymphoides dans l'infiltrat p\u00e9ritumoral dans un cas de nevomatose baso\u2010cellulaire. 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