{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T10:10:33Z","timestamp":1761041433754,"version":"build-2065373602"},"reference-count":42,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,6,15]],"date-time":"2005-06-15T00:00:00Z","timestamp":1118793600000},"content-version":"vor","delay-in-days":6040,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[1988,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The renal biopsies of ten women with preeclampsia without other underlying renal disease were examined in detail using light and electron microscopy and immunofluorescence. Characteristic preeclamptic glomerular lesions with endocapillary cell swelling, subendothelial and mesangial deposits, and mesangial interposition were detected in each patient. Juxtaglomerular regions were not prominent and were poorly granulated on light microscopy; ultra\u2010structurally, they showed myoepithelioid cells with sparse renin granulation and considerable heterogeneity of granule size and density in association with relatively meagre granular endoplasmic reticulum and Golgi profiles. These morphologic findings suggest that, in patients with clinical and renal biopsy evidence of preeclampsia, there is no significant stimulation of the renin\u2013angiotensin system.<\/jats:p>","DOI":"10.1002\/path.1711560404","type":"journal-article","created":{"date-parts":[[2005,6,22]],"date-time":"2005-06-22T09:25:57Z","timestamp":1119432357000},"page":"291-303","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Morphologic changes in the renal glomerulus and the juxtaglomerular apparatus in human preeclampsia"],"prefix":"10.1002","volume":"156","author":[{"given":"Prudence A.","family":"Hill","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth F.","family":"Fairley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priscilla","family":"Kincaid\u2010Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Zimmerman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graeme B.","family":"Ryan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,15]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1980.131"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-196012000-00002"},{"key":"e_1_2_1_4_2","first-page":"271","article-title":"Renal lesions in pregnancy","volume":"17","author":"Hopper J","year":"1961","journal-title":"Obstet Gynecol"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1961.63040090005010"},{"key":"e_1_2_1_6_2","first-page":"518","article-title":"Preeclamptic nephropathy","volume":"11","author":"Mautner W","year":"1962","journal-title":"Lab Invest"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(63)90100-5"},{"key":"e_1_2_1_8_2","first-page":"1682","article-title":"The glomerular capillary wall in human kidney disease, acute glomerulonephritis, systemic lupus erythematosus and preeclampsia\u2013eclampsia","volume":"15","author":"Faith GG","year":"1966","journal-title":"Lab Invest"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006250-196805000-00001"},{"key":"e_1_2_1_10_2","first-page":"109","article-title":"Ultrastructural studies in hypertension IV. 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