{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T09:00:10Z","timestamp":1762160410715,"version":"build-2065373602"},"reference-count":65,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,6,16]],"date-time":"2005-06-16T00:00:00Z","timestamp":1118880000000},"content-version":"vor","delay-in-days":6010,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[1989,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The cutaneous innervation is now known to contain neuropeptides including substance P (SP) and calcitonin generelated peptide (CGRP) in sensory nerves, and vasoactive intestinal polypeptide (VIP) and neuropeptide Y (NPY), principally in autonomic nerves. Skin biopsies from 100 leprosy patients and equivalent areas from 50 non\u2010leprosy controls were fixed in\n                    <jats:italic>p<\/jats:italic>\n                    \u2010benzoquinone solution for immunofluorescence staining, and in Bouin's fluid for classification of leprosy type. Antisera to the neural markers, neurofilaments, and protein gene product 9.5 (PGP 9.5), and to neuropeptides were used. Cutaneous nerves and nerve endings immunoreactive for neuropeptides, neurofilaments, and PGP 9.5 were seen in all non\u2010leprous control cases. In leprosy, PGP 9.5\u2010 and neurofilament\u2010immunoreactive nerve fibres were seen in all 14 cases of the indeterminate (early) type and in the majority (33\/43) of lepromatous cases, but in a smaller proportion (15\/43) of tuberculoid cases. Neuropeptide immunoreactivity was seen in only 2\/14 of the indeterminate leprosy specimens and was completely absent in other types. This early disappearance may be of diagnostic significance. Thus, cutancous sensory and autonomic dysfunctions in leprosy are well reflected by changes in nerve fibres and neuropeptides.\n                  <\/jats:p>","DOI":"10.1002\/path.1711570104","type":"journal-article","created":{"date-parts":[[2005,6,22]],"date-time":"2005-06-22T09:31:14Z","timestamp":1119432674000},"page":"15-26","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":72,"title":["Changes in nerves and neuropeptides in skin from 100 leprosy patients investigated by immunocytochemistry"],"prefix":"10.1002","volume":"157","author":[{"given":"S. S.","family":"Karanth","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. 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